Rapamycin analog as immunosuppressant

Details Rapamycin analog as immunosuppressant Rapamycin analog as immunosuppressant

1992-08-05

1993-04-13

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514183, A61K 31395

Patent

active

052023320

ABSTRACT:
Reduction of the C-33 ketone of rapamycin gives the C-33 hydroxy analog of Formula I. ##STR1## The reduction product prevents cleavage of the C-31/C-32 bond due to base degradation. The Formula I compounds exhibit immunosuppressant, antifungal, and antiinflammatory activities.

REFERENCES:
patent: 5120726 (1992-06-01), Failli et al.
patent: 5138051 (1992-08-01), Hughes et al.

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