Rapamycin acetals as immunosuppressant and antifungal agents

Details Rapamycin acetals as immunosuppressant and antifungal agents Rapamycin acetals as immunosuppressant and antifungal agents

1991-11-06

1992-09-29

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

514291, 540452, 540456, A61K 31695, A61K 31395, C07D49816, C07D 704

Patent

active

051514133

ABSTRACT:
Derivatives of Rapamycin where the hydroxy group at position 31 and/or 42 are reacted with acetal forming reagents have been shown to have immunosuppressant and antifungal properties. These derivatives are represented by the formula: ##STR1## wherein R.sup.1 and R.sup.2 independently are hydrogen, --CH.sub.2 YX, --C(CH.sub.3).sub.2 YX, --CH.sub.2 (CH.sub.3)YX, or L;

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patent: 4316885 (1982-02-01), Rakhit
patent: 4401653 (1983-04-01), Eng
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patent: 4885171 (1989-12-01), Sehgal
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FASEB 3, 3411 (1989).
FASEB 3, 5256 (1989).
Lancet, 1183, (1978).

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