Rapamycin 42-oximes and hydroxylamines

Details Rapamycin 42-oximes and hydroxylamines Rapamycin 42-oximes and hydroxylamines

1996-05-30

1997-10-14

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514291, 546 14, 540456, A61K 3133, A61K 3144, C07D49116, C07D 31445

Patent

active

056772955

ABSTRACT:
A compound of the structure ##STR1## wherein X--Y is C.dbd.NOR.sup.1 or CHNHOR.sup.2 ; R.sup.1 and R.sup.2 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, cycloalkyl, alkyloxy, alkoxyalkyl, cycloalkylaminoalkyl, cyanoalkyl, fluoroalkyl, trifluoromethylalkyl, trifluoromethyl, ArO--, --(CH.sub.2).sub.m Ar, or --COR.sup.3 ;

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