Rapamycin 31-ester with N,N-dimethylglycine derivatives useful a

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514291, C07D49116, A61K 31395

Patent

active

053490606

ABSTRACT:
A derivative of rapamycin of general formula (1) and (2) ##STR1## wherein ##STR2## or hydrogen; R.sup.2 =hydrogen, or lower alkyl having 1 to 6 carbon atoms; ##STR3## wherein X=hydrogen, lower alkyl having 1 to 6 carbon atoms, --CF.sub.3, --NO.sub.2, --OR.sup.2, NR.sup.2, SR.sup.2, or halogen; R.sup.4 =lower alkyl, alkenyl or alkynyl having 1 to 6 carbon atoms or an aromatic or heterocyclic moiety selected from the group consisting of phenyl, naphthyl, thiophenyl and quinolinyl;

REFERENCES:
patent: 3929992 (1975-12-01), Sehgal
patent: 3993749 (1976-11-01), Sehgal et al.
patent: 4316885 (1982-02-01), Rakhit
patent: 4401653 (1983-08-01), Eng
patent: 4650803 (1987-03-01), Stella
patent: 4885171 (1989-12-01), Sehgal et al.
patent: 5078999 (1992-01-01), Warner et al.
patent: 5080899 (1992-01-01), Sturm et al.
patent: 5091389 (1992-02-01), Ondeyka
patent: 5100883 (1992-03-01), Schiehser
patent: 5100899 (1992-03-01), Calne
patent: 5102876 (1992-04-01), Caufield
patent: 5118677 (1992-06-01), Caufield
patent: 5120842 (1992-06-01), Failli et al.
patent: 5130307 (1992-07-01), Failli et al.
patent: 5138051 (1992-08-01), Hughes et al.
patent: 5151413 (1992-09-01), Caufield et al.
patent: 5169851 (1992-12-01), Hughes et al.
patent: 5177203 (1993-01-01), Failli et al.
patent: 5194447 (1993-03-01), Kao
Can. J. Physiol. Pharmacol. 55, 48 (1977).
Vezina, C., J. Antibiot. 28: 721 (1975).
Sehgal, S. N., J. Antibiot. 28: 727 (1975).
Baker, H. J., Antibiot. 31: 539 (1978).
Meiser et al., J. Heart Lung Transplant 9: 55 (1990).
Stepkowski, S. M., Transplantation Proc. 23: 507 (1991).
Staruch, M. J., FASEB 3: 3411 (1989).
Dumont, F. J., FASEB 3: 5256 (1989).
Calne, R. Y., Lancet 1183 (1978).
Morris, R. E., Med. Sci. Res. 17: 877 (1989).
Baeder, W. L., Fifth Intl. Conf. Inflamm. Res. Assoc. 121 (Abstract) (1990).
Gregory et al., J. Heart Lung Transplant II (pt 2): 197 (1992) 9942-1-C1 (p. 1).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Rapamycin 31-ester with N,N-dimethylglycine derivatives useful a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Rapamycin 31-ester with N,N-dimethylglycine derivatives useful a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Rapamycin 31-ester with N,N-dimethylglycine derivatives useful a will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2429989

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.