Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1997-09-24
2000-01-18
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
930140, 424 851, C07K 1452, A61K 3819
Patent
active
060158832
ABSTRACT:
The present invention provides a polynucleotide (PTEC) isolated from a prostate cDNA library which identifies and encodes a novel human rantes homolog PTEC (prostate expressed chemokine). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PTEC. The invention also provides for the therapeutic use of purified PTEC in the treatment of immune deficiency diseases, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of conditions or diseases associated with the expression of PTEC. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
REFERENCES:
patent: 5605817 (1997-02-01), Coleman et al.
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Callard et al., The Cytokine Facts Book, Academic Press, San Diego, CA, pp. 226-227, 180-187 (1994).
Covell et al., "Analysis of Hydrophobicity in the .alpha. and .beta. chemokine families and its relevance to dimerization," Protein Science, 3:2064-72 (1994).
Meurer et al., "Formation of Eosinophilic and Monocytic Intradermal Inflammatory . . . ," J. Exp. Med., 178:1913-1921 (1993).
Schall et al., "A Human T Cell-Specific Molecule Is A Member of a New Gene Family", The Journal of Immunology, 141(3):1018-1025, (1988).
Shin et al., "Definition of a Lipopolysaccharide-Responsive Element in the 5'-Flanking Regions of MuRantes and crg-2", Molecular and Cellular Biology, 14(5):2914-2925.
Bandman Olga
Hawkins Phillip R.
Murry Lynn E.
Draper Garnette D.
Incyte Pharmaceuticals Inc.
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