Ranitidine pharmaceutical compositions

Details Ranitidine pharmaceutical compositions Ranitidine pharmaceutical compositions

1994-01-13

1995-10-10

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424456, 424464, 424465, 424489, A61K 948

Patent

active

054569184

ABSTRACT:
The invention provides a pharmaceutical composition for use in human or veterinary medicine which comprises ranitidine or a physiologically acceptable salt thereof, alginic acid or a physiologically acceptable salt thereof, and a carbonate or bicarbonate. The composition preferably comprises 1.25% to 10% w/w ranitidine hydrochloride, 5% to 35% w/w alginic acid, and 2% to 15% w/w sodium bicarbonate and is preferably in the form of a capsule or tablet. The compositions are suitable for the treatment of gastrointestinal disorders and particularly reflux oesophagitis.

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Finn et al., Gastroenterology, 94(5), pt. 11, A128, May 1988.
Russell et al., Am. J. Gastroenterology, 83(9), 1025, Oct. 1988.
Anon, "Antiulcer Combinations for Reflux", Mims, 19, Apr. 15, 1988.
Chandra et al., Br. J. Clin. Pract., 43, 3, Mar. 1989.
Swinyard; "Gastrointestinal Drugs"; Remingtons Pharmaceutical Sciences; Chapter 39; pp. 774-778.

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