Randomized libraries of zinc finger proteins

Details Randomized libraries of zinc finger proteins Randomized libraries of zinc finger proteins

2003-01-06

2009-02-17

Brusca, John S (Department: 1631)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S419000, C435S320100

Reexamination Certificate

active

07491531

ABSTRACT:
The present invention relates to methods of using libraries of randomized zinc finger proteins to identify genes associated with selected phenotypes.

REFERENCES:
patent: 4990607 (1991-02-01), Katagiri et al.
patent: 5096814 (1992-03-01), Aivasidis et al.
patent: 5096815 (1992-03-01), Ladner et al.
patent: 5173414 (1992-12-01), Lebkowski et al.
patent: 5198346 (1993-03-01), Ladner et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5243041 (1993-09-01), Fernandez-Pol
patent: 5302519 (1994-04-01), Blackwood et al.
patent: 5324638 (1994-06-01), Tao et al.
patent: 5324818 (1994-06-01), Nabel et al.
patent: 5324819 (1994-06-01), Oppermann et al.
patent: 5340739 (1994-08-01), Stevens et al.
patent: 5348864 (1994-09-01), Barbacid
patent: 5350840 (1994-09-01), Call et al.
patent: 5356802 (1994-10-01), Chandrasegaran
patent: 5376530 (1994-12-01), De The et al.
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5436150 (1995-07-01), Chandrasegaran
patent: 5487994 (1996-01-01), Chandrasegaran
patent: 5498530 (1996-03-01), Schatz et al.
patent: 5578483 (1996-11-01), Evans et al.
patent: 5597693 (1997-01-01), Evans et al.
patent: 5639592 (1997-06-01), Evans et al.
patent: 5674738 (1997-10-01), Abramson et al.
patent: 5702914 (1997-12-01), Evans et al.
patent: 5789538 (1998-08-01), Rebar et al.
patent: 5792640 (1998-08-01), Chandrasegaran
patent: 5869618 (1999-02-01), Lippman et al.
patent: 5871902 (1999-02-01), Weininger et al.
patent: 5871907 (1999-02-01), Winter et al.
patent: 5916794 (1999-06-01), Chandrasegaran
patent: 5939538 (1999-08-01), Leavitt et al.
patent: 5972615 (1999-10-01), An et al.
patent: 6001885 (1999-12-01), Vega et al.
patent: 6007988 (1999-12-01), Choo et al.
patent: 6013453 (2000-01-01), Choo et al.
patent: 0 873 567 (1998-04-01), None
patent: WO 94/05700 (1994-03-01), None
patent: WO 95/19431 (1995-07-01), None
patent: WO 96/06110 (1996-02-01), None
patent: WO 96/06166 (1996-02-01), None
patent: WO 96/11267 (1996-04-01), None
patent: WO 96/20951 (1996-07-01), None
patent: WO 96/32475 (1996-10-01), None
patent: WO 97/27212 (1997-07-01), None
patent: WO 97/27213 (1997-07-01), None
patent: WO 98/53057 (1998-11-01), None
patent: WO 98/53058 (1998-11-01), None
patent: WO 98/53059 (1998-11-01), None
patent: WO 98/53060 (1998-11-01), None
patent: WO 98/54311 (1998-12-01), None
patent: WO 99/35494 (1999-07-01), None
patent: WO 99/36553 (1999-07-01), None
patent: WO 99/41371 (1999-08-01), None
patent: WO 99/42474 (1999-08-01), None
patent: WO 99/45132 (1999-09-01), None
patent: WO 99/47656 (1999-09-01), None
patent: WO 99/48909 (1999-09-01), None
patent: WO 00/23464 (2000-04-01), None
patent: WO 00/27878 (2000-05-01), None
Agarwal et al., “Stimulation of Transcript Elongation Requires Both the Zinc Finger and RNA Polymerase II Binding Domains of Human TFIIS,”Biochemistry30(64):7842-7851 (1991).
Antao et al., “A Thermodynamic Study of Unusually Stable RNA and DNA Hairpins,”Nuc. Acids. Res. 19(21):5901-5905 (1991).
Barbas, C. F., “Recent Advances in Phage Display,”Curr. Opin. Biotech. 4:526-530 (1993).
Barbas et al., “Assembly of Combinatorial Antibody Libraries on Phage Surfaces: The Gene III Site,”PNAS88:7978-7982 (1991).
Barbas et al., “Semisynthetic Combinatorial Antibody Libraries: A Chemical Solution to the Diversity Problem,”PNAS89:4457-4461 (1992).
Beerli et al., “Toward Controlling Gene Expression at Will: Specific Regulation of the erbB-2/HER-2 Promoter by Using Polydactyl Zinc Finger Proteins Constructed From Modular Building Blocks,”Proc. Natl. Acad. Sci. U.S.A. 95:14628-14633 (1998).
Bellefroid et al., “Clustered Organization of Homologous KRAB Zinc-Finger Genes With Enhanced Expression in Human T Lymphoid Cells,”EMBO J. 12(4):1363-1374 (1993).
Berg, J.M., “DNA Binding Specificity of Steroid Receptors,”Cell57:1065-1068 (1989).
Berg, J.M., “Sp1 and the Subfamily of Zinc-Finger Proteins with Guanine-Rich Binding Sites,”PNAS89:11109-11110 (1992).
Berg et al., “The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc,”Science271:1081-1085 (1996).
Berg, J.M., “Letting Your Fingers do the Walking,”Nature Biotechnology15:323 (1997).
Bergqvist et al., “Loss of DNA-binding and new Transcriptional Trans-Activation Function in Polyomavirus Large T-Antigen with Mutation of Zinc Finger Motif,”Nuc. Acids Res. 18(9):2715-2720 (1990).
Blaese et al., “Vectors in Cancer Therapy: How Will They Deliver?,”Cancer Gene Therapy2(4):291-297 (1995).
Buchscher et al., “Human Immunodeficiency Virus Vectors for Inducible Expression of Foreign Genes,”Journal of Virology66(5):2731-2739 (1992).
Caponigro et al., “Transdominant Genetice Analysis of a Growth Control Pathyway,”Proc. Natl. Acad. Sci. U.S.A. 95:7508-7513 (1998).
Celenza et al., “A Yeast Gene That Is Essential for Release from Glucose Repression Encodes a Protein Kinase,”Science233:1175-1180 (1986).
Cheng et al., “Identification of Potential Target Genes for Adrip through Characterization of Essential Nucleotides in UASI,”J. Mol. Cellular Biol. 14(6):3842-3852 (1994).
Cheng et al., “A Single Amino Acid Substitution in Zinc Finger 2 of Adrip Changes its Binding Specificity at two Positions in UAS1,”.J. Mol. Biol. 251:1-8 (1995).
Choo et al., A Role in DNA-Binding for the Linker Sequences of the First Three Zinc Fingers of TFIIIANuc. Acids Res. 21(15):3341-3346 (1993).
Choo et al., “Promoter-Specific Activation of Gene Expression Directed By Bacteriophage-Selected Zinc Fingers,”J. Mol. Biol. 273:525-532 (1997).
Choo et al., “Designing DNA-Binding Proteins on the Surface of Filamentous Phage,”Curr. Opin. Biotechnology6:431-436 (1995).
Choo, Y., “Recognition of DNA Methylation by Zinc Fingers,”Nature Struct Biol. 5(4):264-365 (1998).
Choo et al., “All Wrapped Up,”Nature Structural Biology5(4):253-255 (1998).
Choo, Y., “End Effects in DNA Recognition by Zinc Finger Arrays,”Nuc. Acids. Res. 26(2):554-557 (1998).
Choo et al., Physical Basis of Protein-DNA Recognition Code,Curr. Opin. Struct. Biol. 7(1):117-125 (1997).
Choo et al., “In Vivo Repression by a Site-Specific DNA-Binding Protein Designed Against an Oncogenic Sequence,”Nature372:642-645 (1994).
Choo et al., “Selection of DNA Binding Sites for Zinc Fingers Using Rationally Randomized DNA Reveals Coded Interactions,”Proc. Natl. Acad. Sci. U.S.A. 91:11168-11172 (1994).
Choo et al., “Toward a Code for the Interactions of Zinc Fingers With DNA: Selection of Randomized Fingers Displayed on Phage,”Proc. Natl. Acad. Sci. U.S.A. 91:11163-11167.
Clark et al., “Zinc Fingers inCaenorhabditis elegans: Finding Families and Probing Pathways,”Science282:2018-2022 (1998).
Corbi et al., “Synthesis of a New Zinc Finger Peptide: Comparison of Its “Cod” Deduced and CASTing Derived Binding Sites,”FEBS Letters417:71-74 (1997).
Crozatier et al., “Single Amino Acid Exchanges in Separate Domains of the Drosophila Serendipity δ Zinc Finger Protein Cause Embroyonic and Sex Biased Lethality,”Genetics131:905-916 (1992).
Debs et al., Regulation of Gene Expression in Vivo by Liposome-Mediated Delivery of a Purified Transcription Factor,J. Biological Chemistry265(18):10189-10192 (1990).
Desjarlais et al., “Redesigning the DNA-Binding Specificity of a Zinc Finger Protein: A Data Base-Guided Approach,”Proteins: Structure, Function, and Genetics12(2):101-104 (1992).
Desjarlais et al., “Redesigning the DNA-Binding Specificity of a Zinc Finger Protein: A Data Base-Guided Approach,”Proteins: Structure, Function, and Genetics13(3):272 (1992).
Desjarlais, J. R. and Berg, J.M., “Length-Encoded Multiplex binding Suite Determination: Application to Zinc Finger Proteins,”Proc. Natl. Acad. Sci. U.S.A. 91:11099-11103 (1994).
Desjarlais, J. R.

Affiliated with

Also associated with

Rating

Randomized libraries of zinc finger proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Randomized libraries of zinc finger proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Randomized libraries of zinc finger proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4112915