Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Reexamination Certificate
2006-05-30
2006-05-30
Campell, Bruce R. (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
C514S021800, C424S185100
Reexamination Certificate
active
07053177
ABSTRACT:
This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastrointestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.
REFERENCES:
patent: 5338665 (1994-08-01), Schatz et al.
patent: 5498538 (1996-03-01), Kay et al.
patent: 5620855 (1997-04-01), Dantzig
patent: 6117632 (2000-09-01), O'Mahony
patent: WO 91/19818 (1991-12-01), None
patent: WO 94/07530 (1994-04-01), None
patent: WO 94/18318 (1994-08-01), None
patent: WO 95/29938 (1995-11-01), None
Balass et al., 1993, “Identification of a hexapeptide that mimics a conformation-dependent binding site of acetylcholine receptor by use of a phage-epitope library”, Proc. Natl. Acad. Sci. USA 90:10638-10642.
Bass et al., 1990, “Hormone phage: an enrichment method for variant proteins with altered binding properties”, Proteins: Struct. Func. Genet. 8:309-314.
Cesareni, 1992, “Peptide display on filamentous phage capsids”, FEBS Lett. 307:66-70.
Christian et al., 1992, “Simplified methods for construction, assessment and rapid screening of peptide libraries in bacteriophage”, J. Mol. Biol. 227:711-718.
Cwirla et al., 1990, “Peptides on phage: A vast library of peptides for identifying ligands”, Proc. Natl. Acad. Sci. USA 87:6378-6382.
Davis and Jllum, 1994, “Particulate systems for site specific drug delivery”, In: Targeting of Drugs 4 (Eds), Gregoriadis, McCormack and Poste, 183-194.
De la Cruz et al., 1988, “Immunogenicity and epitope mapping of foreign sequences via genetically engineered filamentous phage”, J. Biol. Chem. 263:4318-4322.
Devlin et al., 1990, “Random peptide libraries: a source of specific protein binding molecules”, Science 249:404-406.
Evers, 1995, Developments in Drug Delivery: Technology and Markets, Financial Times Management Report, p. 1-26.
Fix, 1996, “Strategies for delivery of peptides utilizing absorption-enhancing agents”, J. Pharmac. Sci. 85:1282-1285.
Fodor et al., 1991, “Light-directed, spatially addressable parallel chemical synthesis”, Science 251:767-773.
Fong et al., 1994, “Scanning whole cells with phage-display libraries: identification of peptide ligands that modulate cell function”, Drug Development Research 33:64-70.
Gallop et al., 1994, “Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries”, J. Med. Chem. 37:1233-1251.
Greenwood et al., 1991, “Multiple display of foreign peptides on a filamentous bacteriophage”, J. Mol. Biol. 220:821-827.
Houghten et al., 1991, “Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery”, Nature 354:84-86.
Hoogenboom et al., 1991, “Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) haevy and light chains”, Nucleic Acids Res. 19:4133-4137.
Kang et al., 1991, “Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces”, Proc. Natl. Acad. Sci. USA 88:4363-4366.
Kay et al., 1993, “An M13 phage library displaying random 38-amino-acid peptides as a source of novel sequences with affinity to select targets”, Gene 128:59-65.
Lam et al, “A new type of synthetic peptide library for identifying ligand-binding activity”, Nature 354:82-84.
Liang et al., 1995, “Human intestinal H+/peptide cotransporter: cloning, functional expression, and chromosomal localization,” J. Biol. Chem. 270:6456-6463.
Lowman et al., 1991, “Selecting high-affinity binding proteins by monovalent phage display”, Biochemistry 30:10832-10838.
Marks et al., 1991, “By-passing immunization: human antibodies from V-gene libraries displayed on phage”, J. Mol. Biol. 222:581-597.
McCafferty et al., 1990, “Phage antibodies: filamentous phage displaying antibody variable domains”, Nature 348:552-554.
Parmley and Smith, 1988, “Antibody-selectable filamentous fd phage vectors: affinity purification of target genes”, Gene 73:305-318.
Parmley and Smith, 1989, “Filamentous fusion phage cloning vectors for the study of epitopes and design of vaccines”, Adv. Exp. Med. Biol. 251:215-218.
Peterson and Mooseker, 1992, “Characterization of the enterocyte-like brush border cytoskeleton of the C2BBeclones of the human intestinal cell line, Caco-2”, J. Cell Science 102:581-600.
Pietersz, 1990, “The linkage of cytotoxic drugs to monoclonal antibodies for the treatment of cancer”, Bioconjugate Chem. 1:89-95.
Saito et al., 1997, “Cloning and characterization of a pH-sensing regulatory factor that modulates transport activity of the human H+/peptide cotransporter, PEPT1,” Biochem. and Biophys. Res. Commun. 237:577-582.
Scott and Smith, 1990, “Searching for peptide ligands with an epitope library”, Science 249:386-390.
Smith, 1985, “Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface”, Science 228:1315-1317.
Stevenson et al., 1995, “Permeability screen for synthetic peptide combinatorial libraries using CACO-2 cell monolayers and LC/MS/MS”, Pharmaceutical Res. 12(9), S94.
Yayon et al., 1993, “Isolation of peptides that inhibit binding of basic fibroblast growth factor to its receptor from a random phage-epitope library”, Proc. Natl. Acad. Sci. USA 90:10643-10647.
Alvarez Vernon L.
Belinka, Jr. Benjamin A.
Cagney Gerard M.
Carter John M.
Lambkin Imelda J.
Campell Bruce R.
Cytogen Corporation
Morgan Lewis & Bockius
Teller Roy
LandOfFree
Random peptides that bind to gastro-intestinal tract (GIT)... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Random peptides that bind to gastro-intestinal tract (GIT)..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Random peptides that bind to gastro-intestinal tract (GIT)... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3573821