Random oligonucleotide libraries and methods of making the same

Details Random oligonucleotide libraries and methods of making the same Random oligonucleotide libraries and methods of making the same

1996-12-16

1999-12-14

Guzo, David

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 254, 536 2541, C07H 2100

Patent

active

06001993&

ABSTRACT:
The present invention provides methods of analyzing and evaluating phosphorus bearing monomeric units as to their suitability for use in preparing randomer oligomer libraries. The invention further provides methods for preparing such randomer oligomer libraries from the selected monomers.

REFERENCES:
patent: 3687808 (1972-08-01), Merigan et al.
patent: 5587471 (1996-12-01), Cook et al.
Perbal, "A Practical Guide to Molecular Cloning," 2nd Edition, John Wiley and Sons, New York, 1988, pp. 387-393.
Anderson et al., "Synthesis of Pyrazolo [3,4-d] Pyrimidine Ribonucleoside 3', 5'-Cyclic Phosphates Related to cAMP, cIMP and cGMP", Nucleosides and Nucleotides, 1987, 6, 853-863.
Nord et al., "Synthesis, Structure, and Biological Activity of Certain 2-Deoxy-.beta.-D-ribo-hexopyranosyl Nucleosides and Nucleotides", J. Med. Chem., 1987, 30, 1044-1054.
Ugarkar et al., "A Simple Oxidation of Formycin to Oxoformycin B. Synthesis of 6-Methyloxoformycin, a C-Nucleoside Analog of Doridosine", J. Heterocyclic Chem, 1984, 21, 1865-1870.

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