Raman-active reagents and the use thereof

Details Raman-active reagents and the use thereof Raman-active reagents and the use thereof

2001-09-24

2010-11-02

Cheu, Jacob (Department: 1641)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

C436S173000, C436S164000

Reexamination Certificate

active

07824926

ABSTRACT:
The present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Raman-active reporter molecule, a binding molecule, and a surface enhancing particle capable of causing surface enhanced Raman scattering (SERS). The Raman-active reporter molecule and the binding molecule are affixed to the particle to give both a strong SERS signal and to provide biological functionality, i.e. antigen or drug recognition. The Raman-active reagents can function as an alternative to fluorescence-labeled reagents, with advantages in detection including signal stability, sensitivity, and the ability to simultaneously detect several biological materials. The Raman-active reagents also have a wide range of applications, especially in clinical fields (e.g., immunoassays, imaging, and drug screening).

REFERENCES:
patent: 5252459 (1993-10-01), Tarcha et al.
patent: 5266498 (1993-11-01), Tarcha et al.
patent: 5376556 (1994-12-01), Tarcha et al.
patent: 5445972 (1995-08-01), Tarcha et al.
patent: 5567628 (1996-10-01), Tarcha et al.
patent: 6319670 (2001-11-01), Sigal et al.
patent: WO 99/44065 (1999-09-01), None
C.R. Martin and D.T. Mitchell, “Nanomaterials in Analytical Chemistry,”Analytical Chemistry News&Features, pp. 322-327 (May 1, 1998).
S. Nie and S.R. Emory, “Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering,”Science, 275:1102-1106 (1997).

Affiliated with

Also associated with

Rating

Raman-active reagents and the use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Raman-active reagents and the use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Raman-active reagents and the use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4177283