Rage-related methods for treating inflammation

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

Reexamination Certificate

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C424S133100, C424S134100, C424S143100, C514S825000

Reexamination Certificate

active

09872185

ABSTRACT:
The present invention provides a method for treating inflammation in a subject which comprises administering to the subject soluble receptor for advanced glycation endproduct (sRAGE) in an amount effective to inhibit binding of advanced glycation endproducts (AGEs) to RAGE thereby treating inflammation in the subject. The present invention also provides for a method for treating inflammation in a subject which comprises administering to the subject an agent in an amount effective to inhibit the interaction between receptor for advanced glycation endproduct (RAGE) and its ligand thereby treating inflammation in the subject.

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patent: 2003/0059423 (2003-03-01), Stern et al.
patent: WO 00/20621 (2000-04-01), None
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Schmidt. A.M., SD Yan. and D. Stern.(1995). The Dark Side of Glucose (News and Views). Nature Medicine 1:1002-1004. (Exhibit 4).
Schmidt, A.M., Vianna.M., Gerlach. M., Brett. J., Ryan. J., Kao. J., Esposito. C., Hegarty. H., Hurley. W., Clauss. M., Wang. F., Pan. Y.C., Tsang. T.C. and Stern. D. (1992). Isolation and characterization of binding proteins for advanced glycosylation endproducts from lung tissue which are present on the endothelial cell surface. J.Biol. Chem. 267,14987-14997.(Exhibit 5).
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Hori O., J. Brett. T. Slattery, R. Cao. J.Zhang. J. Chen, M. Nagashima, D. Nitecki, J. Morser, D. Stern. A.M. Schmidt.(1995). The Receptor for Advanced Glycation Endproducts (RAGE) is a cellular binding site for amphoterin: mediation of neurite outgrowth and co-expression of RAGE and amphoterin in the developing nervous system. J.Biol. Chem. 270:25752-25761. (Exhibit 7).
Schmidt, A-M. et al. (1994). Cellular Receptors for Advanced Glycation Endproducts.Arterioscler. Thromb., 14:1521-1528. (Exhibit 8).
Schmidt. A-M. et al. (1994). Receptor for advanced glycation endproducts (AGEs) has a central role in vessel wall interactions and gene activation in response to circulating AGE proteins.Proc. Natl. Acad. Sci.(USA). 91:8807-8811. (Exhibit 9).
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U.S. Appl. No. 60/469,428, filed May 9, 2003, Schmidt et al.
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