Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2005-07-20
2008-12-30
Spector, Lorraine (Department: 1647)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C424S192100, C536S023400, C435S069700, C435S325000, C435S344100, C435S091400, C435S252300
Reexamination Certificate
active
07470521
ABSTRACT:
The present invention is drawn to fusion proteins comprising a Receptor for Advanced Glycation Endproducts (RAGE) and an immunoglobulin element. The invention also encompasses methods of treating a condition characterized by activation of an inflammatory cytokine cascade comprising administering such fusion proteins. The invention is also drawn to nucleic acids encoding the fusion proteins, as well as vectors and cells comprising such nucleic acids.
REFERENCES:
patent: 5753230 (1998-05-01), Brooks et al.
patent: 5852174 (1998-12-01), Vlassara et al.
patent: 5864018 (1999-01-01), Morser et al.
patent: 6228642 (2001-05-01), Baker et al.
patent: 6465422 (2002-10-01), Schmidt et al.
patent: 6468555 (2002-10-01), Nakamura
patent: 6555340 (2003-04-01), Schmidt et al.
patent: 6555651 (2003-04-01), Stern et al.
patent: 6613801 (2003-09-01), Mjalli et al.
patent: 7189830 (2007-03-01), Gillies et al.
patent: 2001/0039256 (2001-11-01), Stern et al.
patent: 2001/0053357 (2001-12-01), Stern et al.
patent: 2002/0006957 (2002-01-01), Mjalli et al.
patent: 2002/0106726 (2002-08-01), Schmidt et al.
patent: 2002/0116725 (2002-08-01), Stern et al.
patent: 2002/0122799 (2002-09-01), Stern et al.
patent: 2002/0193432 (2002-12-01), Mjalli et al.
patent: 2003/0032663 (2003-02-01), Mjalli et al.
patent: 2003/0144201 (2003-07-01), Tracey et al.
patent: 2004/0082542 (2004-04-01), Mjalli et al.
patent: 2005/0033017 (2005-02-01), Yamamoto et al.
patent: 2006/0078562 (2006-04-01), Mjalli et al.
patent: 2006/0140933 (2006-06-01), Pittman et al.
patent: WO 97/08321 (1997-03-01), None
patent: WO 97/39121 (1997-10-01), None
patent: WO 00/78815 (2000-12-01), None
patent: WO 01/12598 (2001-02-01), None
patent: WO 01/92210 (2001-12-01), None
patent: WO 02/30889 (2002-04-01), None
patent: WO 02/069965 (2002-09-01), None
patent: WO 02/070007 (2002-09-01), None
patent: WO 02/070667 (2002-09-01), None
patent: WO 02/074805 (2002-09-01), None
patent: WO 02/092004 (2002-11-01), None
patent: WO 03/075921 (2003-09-01), None
patent: WO 2004/016229 (2004-02-01), None
patent: WO 2005/026209 (2005-03-01), None
patent: WO 2005/051995 (2005-06-01), None
Huttunen, H.J. et al., “Receptor for Advanced Glycation End Products-Binding COOH-terminal Motif of Amphoterin Inhibits Invasive Migration and Metastasis,”Cancer Research, 62(16):4805-4811 (2002).
R & D Systems, Product Specifications and Use: “Recombinant Human RAGE/Fc Chimera” Catalog No. 1145-RG, (2004).
Rouhiainen, A., et al., “Regulation of Monocyte Migration by Amphoterin (HMGB1),”Blood, 104(4):1174-1182 (2004).
Schmidt, A., et al., “The Multiligand Receptor RAGE as a Progression Factor Amplifying Immune and Inflammatory Responses,”J. Clin. Invest., 108 (7):949-955 (2001).
Chavakis, T., et al., “The Pattern Recognition Receptor (RAGE) is a Counterreceptor for Leukocyte Integrins: A Novel Pathway for Inflammatory Cell Recruitment,”J. Exp. Med., 198 (10):1507-1515 (2003).
Neeper, M., et al., “Cloning and Expression of a Cell Surface Receptor for Advanced Glycosylation End Products of Proteins,”J. Biol. Chem., 267(21):14998-15004 (1992).
Ojwang, J.O., et al., “Modified Antisense Oligonucleotides Directed Against Tumor Necrosis Factor Receptor Type I Inhibit Tumor Necrosis Factor α-mediated Functions,”Biochemistry, 36:6033-6045 (1997).
Pamfer, S., et al., “Neutralization of Tumor Necrosis Factor α (TNF α) Action on Cell Proliferation in Rat Blastocysts by Antisense Oligodeoxyribonucleotides Directed Against TNF α p60 Receptor,”Biol. Reprod., 52:1316-1326 (1995).
Yahata, N., et al., “Antisense Phosphorothioate Oligonucleotide Inhibits Interleukin 1β Production in the Human Macrophage-like Cell Line, U937,”Antisense Nucleic Acid Drug Dev., 6:55-61 (1996).
Leavitt, M.C., et al., “Inhibition of Interleukin-1β (IL-1β) Production in Human Cells by Ribozymes Against IL-1β and IL-1β Converting Enzyme (ICE),”Antisense Nucleic Acid Drug Dev., 10:409-414 (2000).
Taylor, M.F., et al., “Effect of TNF-α Antisense Oligomers on Cytokine Production by Primary Murine Alveolar Macrophages,”Antisense Nucleic Acid Drug Dev., 8(3):199-205 (1998).
Hendrix, C., et al., “Selection of Hammerhead Ribozymes for Optimum Cleavage of Interleukin 6 mRNA,”Biochem. J., 314(Pt 2):655-661 (1996).
Kam, L.Y. and S.R. Targan, “TNF-α Antagonists for the Treatment of Crohn's Disease,”Expert Opin. Pharmacother., 1:615-622 (2000).
Nagahira, K., et al., “Humanization of a Mouse Neutralizing Monoclonal Antibody Against Tumor Necrosis Factor-α (TNF-α),”J. Immunol. Methods, 222:83-92 (1999).
Lavine, S.D., et al., “Circulating Antibody Against Tumor Necrosis Factor-alpha Protects Rat Brain from Reperfusion Injury,”J. Cereb. Blood Flow Metab., 18(1):52-58 (1998).
Holmes, S., et al., “Characterization of the In Vitro and In Vivo Activity of Monoclonal Antibodies to Human IL-18,”Hybridoma, 19(5):363-367 (2000).
Yang, H., et al. “HMG-1 Rediscovered as a Cytokine,”Shock, 15(4):247-253 (2001).
Wang, H., et al., “HMG-1 as a Late Mediator of Endotoxin Lethality in Mice,”Science, 285:248-251 (1999).
Scaffidi, P., et al., “Release of Chromatin Protein HMGB1 by Necrotic Cells Triggers Inflammation,”Nature, 418:191-195 (2002).
Wang, H., et al., “Proinflammatory Cytokines (Tumor Necrosis Factor and Interleukin 1) Stimulate Release of High Mobility Group Protein-1 by Pituicytes,”Surgery, 126(2):389-392 (1999).
Andersson, U., et al., “High Mobility Group 1 Protein (HMG-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes,”J. Exp. Med., 192(4):565-570 (2000).
Liliensiek, B., et al., “Receptor for Advanced Glycation End Products (RAGE) Regulates Sepsis but not the Adaptive Immune Response,”J. Clin. Invest., 113(11):1641-1650 (2004).
GenBank Accession No. M91211, “Human Receptor for Advanced Glycosylation End Products (RAGE) mRNA, partial cds” (1993) [online] [retrieved on Mar. 21, 2006]. Retrieved from the Internet: <URL:http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=190845>.
GenBank Accession No. NP—001127, “Homo sapiensAdaptor-related Protein Complex 1, beta 1 Subunit (AP1B1), Transcript Variant 1, mRNA” (2005) [online] [retrieved on Mar. 21, 2006]. Retrieved from the Internet: <URL:http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&val=22027650>.
GenBank Accession No. J00228, “Homo sapiensImmunoglobulin gamma-1 Heavy Chain Constant Region (IGHG1) Gene, Partial cds” (1998) [online] [retrieved on Mar. 21, 2006]. Retrieved from the Internet: <URL:http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&val=184739>.
GenBank Accession No. M91212, “Cow Receptor for Advanced Glycosylation End Products (RAGE) mRNA, Complete cds” (1993) [online] [retrieved on Mar. 21, 2006]. Retrieved from the Internet: <URL:http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&val=163650>.
GenBank Accession No. AAA64970, “HMG-1,” (1995) [online] [retrieved on Mar. 21, 2006]. Retrieved from the Internet: <URL:http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=184251>.
GenBank Accession No. AAB08987, “Non-Histone Chromatin Protein HMG1 [Homo sapiens],” (1996) [online] [retrieved on Mar. 21, 2006]. Retrieved from the Internet: <URL:http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=1435197>.
GenBank Accession No. P07155, “High Mobility Group Protein 1 (HMG-1) (Amphoterin) (Heparin-Binding Protein p30),” (2004) [online] [retrieved on Mar. 21, 2006]. Retrieved from the Internet: <URL:http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=1708258>.
GenBank Accession No. AAA20508,“HMG-1,” (1
Luciano Peter
O'Keefe Theresa
Qin Shixin
Critical Therapeutics, Inc.
Hamilton Brook Smith & Reynolds P.C.
Spector Lorraine
Stoica Elly-Gerald
LandOfFree
RAGE protein derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with RAGE protein derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and RAGE protein derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4026194