Rage fusion proteins

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S387300, C530S402000

Reexamination Certificate

active

07901688

ABSTRACT:
Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.

REFERENCES:
patent: 4867973 (1989-09-01), Goers et al.
patent: 5567677 (1996-10-01), Castensson et al.
patent: 5656261 (1997-08-01), Cerami et al.
patent: 5658570 (1997-08-01), Newman et al.
patent: 5747035 (1998-05-01), Presta et al.
patent: 5843725 (1998-12-01), Sledziewski et al.
patent: 5853703 (1998-12-01), Cerami et al.
patent: 5864018 (1999-01-01), Morser et al.
patent: 5891341 (1999-04-01), Li et al.
patent: 6007865 (1999-12-01), Cerami et al.
patent: 6018026 (2000-01-01), Sledziewski et al.
patent: 6225448 (2001-05-01), Tao et al.
patent: 6267958 (2001-07-01), Andya et al.
patent: 6291646 (2001-09-01), Sledziewski et al.
patent: 6300099 (2001-10-01), Sledziewski et al.
patent: 6323323 (2001-11-01), Sledziewski et al.
patent: 6380165 (2002-04-01), Al-Abed et al.
patent: 6440749 (2002-08-01), Cerami et al.
patent: 6465422 (2002-10-01), Schmidt et al.
patent: 6555340 (2003-04-01), Schmidt et al.
patent: 6555651 (2003-04-01), Stern et al.
patent: 6563015 (2003-05-01), Stern et al.
patent: 6670136 (2003-12-01), Schmidt et al.
patent: 6677299 (2004-01-01), Stern et al.
patent: 6753150 (2004-06-01), Schmidt et al.
patent: 6761888 (2004-07-01), Schenk
patent: 6790443 (2004-09-01), Stern et al.
patent: 6825164 (2004-11-01), Stern et al.
patent: 6908741 (2005-06-01), Shahbaz
patent: 6939545 (2005-09-01), Li et al.
patent: 6998125 (2006-02-01), Hanna et al.
patent: 7026444 (2006-04-01), Schmidt et al.
patent: 7081241 (2006-07-01), Schmidt et al.
patent: 7101838 (2006-09-01), Stern et al.
patent: 7125675 (2006-10-01), Schmidt et al.
patent: 7189830 (2007-03-01), Gillies et al.
patent: 7258857 (2007-08-01), Stern et al.
patent: 7470521 (2008-12-01), O'Keefe et al.
patent: 2001/0039256 (2001-11-01), Stern et al.
patent: 2001/0053357 (2001-12-01), Stern et al.
patent: 2002/0002203 (2002-01-01), Rahbar
patent: 2002/0006391 (2002-01-01), Smith et al.
patent: 2002/0013256 (2002-01-01), Rahbar et al.
patent: 2002/0022234 (2002-02-01), Al-Abed et al.
patent: 2002/0037496 (2002-03-01), Jacobson et al.
patent: 2002/0077293 (2002-06-01), Cahoon et al.
patent: 2002/0082273 (2002-06-01), Bush et al.
patent: 2002/0086282 (2002-07-01), Pillarisetti et al.
patent: 2002/0102604 (2002-08-01), Edwards et al.
patent: 2002/0106726 (2002-08-01), Schmidt et al.
patent: 2002/0116725 (2002-08-01), Stern et al.
patent: 2002/0122799 (2002-09-01), Stern et al.
patent: 2003/0144201 (2003-07-01), Tracey et al.
patent: 2004/0121372 (2004-06-01), Schmidt et al.
patent: 2004/0142391 (2004-07-01), Schmidt et al.
patent: 2004/0228855 (2004-11-01), Stern et al.
patent: 2005/0008649 (2005-01-01), Shin et al.
patent: 2005/0026811 (2005-02-01), Mjalli et al.
patent: 2005/0033017 (2005-02-01), Yamamoto et al.
patent: 2005/0129682 (2005-06-01), Schmidt et al.
patent: 2005/0170382 (2005-08-01), Stern et al.
patent: 2005/0244849 (2005-11-01), Pittman et al.
patent: 2006/0025789 (2006-02-01), Laufer et al.
patent: 2006/0057679 (2006-03-01), O'Keefe et al.
patent: 2006/0078562 (2006-04-01), Mjalli et al.
patent: 2006/0084145 (2006-04-01), Anderson et al.
patent: 2006/0140933 (2006-06-01), Pittman et al.
patent: 2007/0014791 (2007-01-01), Schmidt et al.
patent: 2007/0099829 (2007-05-01), Stern et al.
patent: 2007/0167360 (2007-07-01), Yan et al.
patent: 2008/0019986 (2008-01-01), Stern et al.
patent: 2008/0045455 (2008-02-01), Mjalli et al.
patent: 2008/0075733 (2008-03-01), Mjalli et al.
patent: 2008/0171701 (2008-07-01), Stern
patent: 2008/0199467 (2008-08-01), Mjalli et al.
patent: 2008/0207499 (2008-08-01), Barile
patent: 2008/0214453 (2008-09-01), Stern et al.
patent: 2009/0004190 (2009-01-01), Mjalli et al.
patent: 2009/0060925 (2009-03-01), Mjalli et al.
patent: 2219947 (2003-12-01), None
patent: WO 97/26913 (1779-07-01), None
patent: WO 97/39121 (1997-10-01), None
patent: WO 97/39125 (1997-10-01), None
patent: WO 98/22138 (1998-05-01), None
patent: WO 98/40071 (1998-09-01), None
patent: WO 99/07402 (1999-02-01), None
patent: WO 99/13912 (1999-03-01), None
patent: WO 99/18987 (1999-04-01), None
patent: WO 94/10308 (1999-05-01), None
patent: WO 99/45907 (1999-09-01), None
patent: WO 99/54485 (1999-10-01), None
patent: WO 00/18970 (2000-04-01), None
patent: WO 00/20458 (2000-04-01), None
patent: WO 00/20621 (2000-04-01), None
patent: WO 01/05422 (2001-01-01), None
patent: WO 01/12598 (2001-02-01), None
patent: WO 01/18060 (2001-03-01), None
patent: WO 01/29269 (2001-04-01), None
patent: WO 01/76584 (2001-10-01), None
patent: WO 01/79849 (2001-10-01), None
patent: WO 01/86002 (2001-11-01), None
patent: WO 01/92210 (2001-12-01), None
patent: WO 01/92892 (2001-12-01), None
patent: WO 02/14519 (2002-02-01), None
patent: WO 02/30889 (2002-04-01), None
patent: WO 02/066978 (2002-08-01), None
patent: WO 02/068636 (2002-09-01), None
patent: WO 2004/004661 (2004-01-01), None
patent: WO 2004/016229 (2004-02-01), None
patent: WO 2004/055055 (2004-07-01), None
patent: WO 2005/019429 (2005-03-01), None
patent: WO 2005/049852 (2005-06-01), None
patent: WO 2005/051995 (2005-06-01), None
patent: WO 2005/061538 (2005-07-01), None
patent: WO 2005/108584 (2005-11-01), None
patent: WO 2006/002971 (2006-01-01), None
patent: WO 2006/012373 (2006-02-01), None
patent: WO 2006/012415 (2006-02-01), None
patent: WO 2006/017643 (2006-02-01), None
patent: WO 2006/017647 (2006-02-01), None
patent: WO 2006/036922 (2006-04-01), None
patent: WO 2006/119510 (2006-11-01), None
patent: WO 2007/094926 (2007-08-01), None
patent: WO 2007/130302 (2007-11-01), None
patent: WO 2008/157378 (2008-06-01), None
patent: WO 2008/100470 (2008-08-01), None
Stevenson. Characterization of protein and peptide stability and solubility in non-aqueous solvents. Curr Pharm Biotechnol. Sep. 2000;1(2):165-82.
Arancio, O. et al., RAGE potentiates Aβ-induced Perturbation of Neuronal Function in Transgenic Mice, EMBO Journal, Vo. 23, pp. 4096-4105, 2004.
Ausubel, F. et al., Short Protocols of Molecular Biology, 4thEdition, Chapter 2, 1999.
Chelius et al., “Formation of Pyroglutamic Acid from N-Terminal Glutamic Acid in Immunoglobulin Gamma Antibodies” Analytical Chemistry, 78:2370-2376, (2006).
Dec. 10, 2008 Office Action issued in connection with U.S. Appl. No. 11/197,644.
Feb. 3, 2009 Office Action issued in connection with U.S. Appl. No. 10/990,310.
International Search Report for related PCT Application, PCT/US2007/010125, mailed Feb. 22, 2008.
International Search Report for related PCT application, PCT/US2007/001686, mailed Aug. 29, 2007.
International Search Report for related PCT application. PCT/US2005/027705, mailed Nov. 10, 2005.
Jan. 11, 2008 Office Action issued in connection with U.S. Appl. No. 11/197,644.
Mohler, K. et al., Soluble Tumor Necrosis Factor (TNF) Receptors are Effective Therapeutic Agents in Lethal Endotoxemia and Function Simultaneously as Both TNF Carriers and TNF Antafonists, Journal of Immunology, vol. 151, No. 3, pp. 1548-1561, 1993.
Written Opinion of the International Search Authority for related PCT Application, PCT/US2007/010125, mailed Feb. 22, 2008.
Bucciarelli, L. et al., RAGE Blockage Stabilizes established Atherosclerosis in Diabetic Apolipoprotein E-Null Mice, Circulation vol. 106, pp. 2827-2835, 2002.
Bonnardel-Phu, E. et al., Acute Modulation of Albumin Microvascular Leakage by Advanced Glycation Ends Products in Microcirculation of Diabetic Rats in Vivo, Diabetes, vol. 48, pp. 2052-2058, 1999.
Burstein, Y. et al., Partial Amino-Acid Sequence of the Precursor of an Immunoglobulin Light Chain containing NH2-Terminal Pyroglutamic Acid, Proc. Natl. Acad. Sci. USA, vol. 73, No. 8, pp. 2604-2608, 1976.
Degenhardt, T. et al., Chemical Modification of Protein

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Rage fusion proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Rage fusion proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Rage fusion proteins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2702491

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.