Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,...
Reexamination Certificate
2011-03-08
2011-03-08
Kolker, Daniel E. (Department: 1649)
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
C530S387300, C530S402000
Reexamination Certificate
active
07901688
ABSTRACT:
Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
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Mjalli Adnan M. M.
Rothlein Robert
Tian Ye Edward
Webster Jeffrey C.
Emch Gregory S
Kilpatrick & Stockton LLP
Kolker Daniel E.
Transtech Pharma, Inc.
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