Radiotherapeutic immunoconjugates labeled with iodine-125

Details Radiotherapeutic immunoconjugates labeled with iodine-125 Radiotherapeutic immunoconjugates labeled with iodine-125

1990-05-29

1992-07-14

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 8591, 530402, A61K 39395, A61K 4300

Patent

active

051301164

ABSTRACT:
A radiotherapeutic immunoconjugate comprising a tumor specific monoclonal antibody, or fragment thereof, and an Auger electron emitting radionuclide, wherein the tumor specific monoclonal antibody or fragment is capable of tumor nucleus localization of the radionuclide and method of using it is disclosed. The radiotherapeutic immunoconjugate is administered in a therapeutically effective amount to patients having or suspected of having a malignancy reactive with the antibody or fragment.

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