Radioreceptor assay for benzodiazepines in saliva

Details Radioreceptor assay for benzodiazepines in saliva Radioreceptor assay for benzodiazepines in saliva

1981-03-30

1984-02-14

Nucker, Christine M.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

Utilizing isolate of tissue or organ as binding agent

436804, 436815, G01N 3360, A61K 4300

Patent

active

044317425

ABSTRACT:
A radioreceptor assay for benzodiazepines in saliva which comprises measuring the diminution of attachment of a known quantity of radio labeled benzodiazepine to a receptor carrier in the presence of an unknown quantity of unlabeled benzodiazepine in a known amount of human saliva. Benzodiazepines are selected from the following oft-utilized drugs which are also representative types of benzodiazepine; namely, diazepam (Valium), chlordiazepoxide (Librium), nitrazepam (Benzalin), oxazepam (Serax), flurazepam (Dalmane), and clorazepate.
Competitive receptors suitable for the present benzodiazepine radioreceptor assay are from fresh rat frontal cortex. Utilizable receptors are whole brain cortex, human cortex, and striatum.

REFERENCES:
patent: 4058511 (1977-11-01), Singh
patent: 4083948 (1978-04-01), Davis et al.
patent: 4119709 (1978-10-01), Holub
patent: 4191738 (1980-03-01), Dixon
patent: 4197288 (1980-04-01), Snyder
patent: 4239744 (1980-12-01), Paul et al.
The Benzodiazepines, Ed. Garattini, Raven Press, N.Y., 1973, pp. 75-97.
Braestrup et al., Proc. Natl. Acad. Sci., vol. 74, Sep., 1977, pp 3805-3809.
Squires et al., Nature, vol. 266 Apr. 21, 1977, pp. 732-734.

Affiliated with

Also associated with

Rating

Radioreceptor assay for benzodiazepines in saliva does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Radioreceptor assay for benzodiazepines in saliva, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Radioreceptor assay for benzodiazepines in saliva will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2375461