Radioprotectant for peptides labeled with radioisotope

Details Radioprotectant for peptides labeled with radioisotope Radioprotectant for peptides labeled with radioisotope

1997-08-21

1999-10-05

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 149, 514 2, 530300, A61K 5100, A61K 3800, A01N 3718, C07K 200

Patent

active

059619554

ABSTRACT:
A method of ameliorating degradation of radiolabeled peptides, especially radiolabeled proteins such as antibodies, by including povidone, also widely known as polyvinylpyrrolidone or PVP, as a radioprotectant in a composition containing a radiolabeled peptide is described. A radioprotectant composition and a stable peptide-radioisotope composition having povidone are also described. Ascorbic acid or other secondary stabilizers may also be added to the compositions to further enhance radioprotection.

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