Radiopharmaceuticals for localization of thromboembolic disease

Details Radiopharmaceuticals for localization of thromboembolic disease Radiopharmaceuticals for localization of thromboembolic disease

1973-02-20

1983-11-22

Nucker, Christine M.

Expansible chamber devices

424 15, 424 9, A61K 4900, A61K 4300

Patent

active

044168659

ABSTRACT:
The invention relates to radiopharmaceuticals useful for specifically localizing blood clots during the diagnosis and treatment of thromboembolic disorders. In one embodiment, the invention comprises a method for preparing and using radioactive urokinase. A novel process for producing urokinase labeled with technetium-99m involves combination of urokinase with the nuclide in a basic solution containing ferric chloride and ascorbic acid, and then adjusting the pH to give an acidic condition in the solution. Radioactively-labeled streptokinase and fibrinokinase are also used to localize thromboembolic disorders.

REFERENCES:
patent: 3636201 (1972-01-01), Johnson
patent: 3740418 (1973-06-01), Rajamani et al.
patent: 3812245 (1974-05-01), Dugan
Bogolyubov, Nuclear Science Abstracts, vol. 21, No. 20, Oct. 31, 1967, p. 3834, #36623.

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