Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1992-04-02
1994-06-28
Stoll, Robert L.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
534 10, 534 14, 424 185, A61K 4902, A61K 4300
Patent
active
053245024
ABSTRACT:
Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography.
REFERENCES:
patent: 5101041 (1992-03-01), Troutner et al.
Chemical Abstracts: CA77(24)159507G Polarographic studies on Cobalt Chelate Complexes (1972).
Fritz et al., Z. Anorg. Allg. Chem. (1972) vol. 392, No. 3, pp. 271-278.
"Synthesis And Biodistribution Of A Series Of Lipophilic Gallium-67 Tris (Salicylaldimine)".
"A New Myocardial Imaging Agent: Synthesis, Characterization, and Biodistribution of Gallium-68-BAT-TECH", The Journal of Nuclear Medicine, vol 31, No. 10, Oct. 1990, by H. F. Kung, et al., pp. 1635-1640.
"Gallium-68, 1,1,1-Tris (5-Methoxysalicylaldiminomethyl) Ethane: A Potential Tracer for Evaluation of Regional Myocardial Blood Flow", The Journal of Nuclear Medicine, vol. 26, No. 2, Feb. 1985, by M. A. Green, et al., pp. 170-180.
"Copper-62-Labeled Pyruvaldehyde Bis(N.sup.4 -methylthiosemicarbazonato)copper(II): Synthesis and Evaluation as a Positron Emission Tomography Tracer for Cerebral and Myocardial Perfusion", M. A. Green, et al., The Journal of Nuclear Medicine, vol. 31, No. 12, Dec. 1990, pp. 1989-1996.
"The Potential for Generator-Based PET Perfusion Tracers", M. A. Green, The Journal of Nuclear Medicine, vol. 31, No. 10, Oct. 1990, pp. 1641-1645.
"Myocardial Perfusion with Rubidium-82. II. Effects of Metabolic and Pharmacologic Interventions", R. A. Goldstein, et al., The Journal of Nuclear Medicine, vol. 24, No. 10, 1983, pp. 907-915.
"Overview: Diagnosis of Ischemic heart Disease by Noninvasive Techniues", M. H. Crawford, M.D., Circulation, 1991; 84 [Supp. I] I-50-I-51.
"Gallium Tris(Salicylaldimine) Complexes Derived From Functionalized Tripodal Triamines", The Journal of Nuclear Medicine, vol. 32, 1991, by M. A. Green, et al., p. 944.
Ca 100(22): 175464q Woehrle et al., "Polymeric Schiff's base chelates & their precursors . . . ", Polymer Bulletin, 1984, 11(2), 151-8.
Green, "Synthesis and Biodistribution of a Series of Lipophilic ha-67 Tris(Salicylaldimine) Complexes," Journal of Labelled Compounds & Radiopharmaceuticals, vol. XXIII, Nos 10-12, pp. 1227-1229.
Green Mark A.
Tsang Brenda W.
Covert John M.
Purdue Research Foundation
Stoll Robert L.
LandOfFree
Radiopharmaceuticals for imaging the heart does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Radiopharmaceuticals for imaging the heart, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Radiopharmaceuticals for imaging the heart will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2376265