Radiopharmaceutical composition based on technetium-99m and reag

Details Radiopharmaceutical composition based on technetium-99m and reag Radiopharmaceutical composition based on technetium-99m and reag

1982-10-26

1984-05-29

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, A61K 4300, A61K 4900

Patent

active

044514514

ABSTRACT:
Radiopharmaceutical compositions containing complexes of technetium-99m with a complexing agent are prone to time and activity-related decomposition and formation of pertechnetate. Stabilizing agents for such complexes are organic compounds having an amine group and a carboxylic acid group attached to an aromatic ring. A preferred stabilizing agent is the sodium salt of 4-aminobenzoic acid. There are claims to a composition comprising a technetium 99-m complex stabilized by means of the said stabilizing agent; and to a reagent which forms, on addition of an aqueous solution of pertechnetate, a radiopharmaceutical composition, which reagent comprises a tin metal or stannous reducing agent for the pertechnetate, a complexing agent for the reduced technetium, for example a phosphorus-containing bone scanning agent, and a stabilizing agent as defined.

REFERENCES:
patent: 4042676 (1977-08-01), Molinski et al.
patent: 4048296 (1977-09-01), Wolfangel et al.
patent: 4229427 (1980-10-01), Whitehouse
patent: 4232000 (1980-11-01), Fawzi
patent: 4233284 (1980-11-01), Fawzi
patent: 4247534 (1981-01-01), Bevan
patent: 4364920 (1982-12-01), Winchell et al.

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