Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-06-13
1998-02-24
Kelly, C. H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514317, 546208, 546212, 546213, A01N 4340, A01N 4346, A61K 31545
Patent
active
057212430
ABSTRACT:
Novel anticholinergics which are related to vesamicol are particularly useful when radiolabeled for evaluating cholinergic innervation in the living human brain. The cholinergic deficit in the Alzheimer's brain should be identifiable with these radioligands.
REFERENCES:
patent: 3575989 (1971-04-01), Razdan
patent: 4069221 (1978-01-01), Yonan
patent: 4233285 (1980-11-01), Winchell et al.
patent: 4552965 (1985-11-01), Parsons
patent: 4605652 (1986-08-01), Welstead, Jr.
patent: 4624961 (1986-11-01), Welstead, Jr.
patent: 4647446 (1987-03-01), Sargent
patent: 4727041 (1988-02-01), Aroonsakul
patent: 4863919 (1989-09-01), Smith
patent: 4866077 (1989-09-01), Bogeso et al.
patent: 4908370 (1990-03-01), Naylor et al.
patent: 5077035 (1991-12-01), Wieland et al.
Marshall and Parsons, entitled "The Vesicular Acetylcholine Transport System" TINS, vol. 10. No. 4, 1987.
Brittain et al, entitled "The Neuromuscular Blocking, Action of 2-(4-phenylpiperidino) . . . , in European Journal of Pharamacology 8(1969)93-99."
Jung et al, "Radiotracer for Mapping Cholinergic Neurons of the Brain", in Journal of Medicinal Chemistry, 1990., vol. 33. No. 8.
Marien et al, entitled "Quantitative autoradiography of brain binding sites for the vesicular acetylcholine transport blocker . . . " in Proc. Nat'l Acad. Sci. USA 84 (1987). . . ", 1988 Synapse 2:486-493(1988).
Kaufman et al, entitled "Fractional Vesamicol Receptor Occupancy and Acetylcholine Active Transport Inhibition in Synaptic Vesicles" in Molecular Pharmacology 36:452-458, 1988.
Reisine et al, entitled "Pre-and postsynaptic neurochemical alterations in Alzheimer's disease". in Brain Research, 159(1978)477-481.
Rossor et al, entitled "A Post-Mortem Study of the Cholinergic and Gaba Systems in Senile Dementia" in Brain (1982) 105,313-330.
Bowen et al, entitled "Biochemical Assessment of Serotonergic and Cholinergic Dysfuntion and Cerebral Atrophy in Alzherimers Disease" in Journal of Neurchemistry 1983.
Mountjoy et al, entitled "Correlation of Cortical Cholinergic and Gaba Deficits with Quantitatie Neuropathological Findings in Senile Demenita" in Brain (1984) 107, 507-518. 1984.
Kilbourn et al entitled "Mouse Brain Distribution of a Carbon-11 Labeled Vesamicol Derivative: . . . " in LifeSciences 47:21 pp.1155-1963 (1990).
Hanson et al entitled "Radioiodinated 1-substituted-4-phenylpiperazines as Potential Brain Imaging Agents" in Int. J. Nucl. Med. Biol. 12:4 pp.315-320 (1985).
Efange et al entitled "Acyclic Analogues of 2-(4-phenylpiperidino)cyclohexanol(Vesamicol): . . . " in J. Med. Chem. 34:8 2638-2643, 1991.
Chem Abs 112:35592 (1990).
Chem. Abs. 104:144746, 1985.
Chem Abs. 121:179542, 1994.
Efange Simon Mbua Ngale
Parsons Stanley M.
Kelly C. H.
Regents of the University of Minnesota
LandOfFree
Radiopharmaceutical agents for the detection of Alzheimers disea does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Radiopharmaceutical agents for the detection of Alzheimers disea, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Radiopharmaceutical agents for the detection of Alzheimers disea will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1875397