Radiopaque cyanoacrylates

Details Radiopaque cyanoacrylates Radiopaque cyanoacrylates

1982-12-16

1987-12-15

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

424 81, 424150, A61K 4904

Patent

active

047132353

ABSTRACT:
Mixtures of cyanoacrylate monomers and radiopaque additives stable to the monomer produce radiopaque compositions useful in surgical and other applications. The additives useful in the compositions are triiodophenol, tetraiodethylene, iodoform and mixtures thereof. When Iodoform is included in the compositions, at least an equal molar amount of triiodophenol should also be included. The compositions include between 0.5 and 11 mole percent iodine and preferably contain at least 4 mole percent iodine. Inhibitors such as SO.sub.2 and hydroquinone may also be included. The compositions are preferably compounded with cyanoacrylate monomers of greater than 98-percent purity.

REFERENCES:
patent: 3360124 (1967-12-01), Stonehill
patent: 4086266 (1978-04-01), Corey
patent: 4354454 (1982-11-01), Hoffman
Cromwell et al., AJR:132, May, 1979, pp. 799-801.
Neuwirth et al., (I), Am. J. Obstet. Gynecol., 10-1-77, pp. 348-349.
Neuwirth et al., (II), Am. J. Obstet. Gynecol., 4-1980, pp. 951-956.
Physicians Desk Reference for Radiology & Nuclear Medicine (PDR), 1978/79, pp. 74-85.

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