Radionuclide labelled particles useful for radiation synovectomy

Details Radionuclide labelled particles useful for radiation synovectomy Radionuclide labelled particles useful for radiation synovectomy

1993-04-16

1994-06-14

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Coated, impregnated, or colloidal particulate

424 129, 600 4, A61K 4300, A61N 510

Patent

active

053208242

ABSTRACT:
The present invention provides radiation synovectomy compositions for treating inflamed synovium containing a radionuclide complex bound to a substantially insoluble particle as the radiolabelled synovectomy agent in a sufficient amount of provide satisfactory synovectomy of the inflamed synovium together with a pharmaceutically acceptable vehicle, the radionuclide being a beta emitter that will substantially ablate the inflamed synovium, but not significantly damage underlying articular cartilage, the radionuclide complex being substantially kinetically stable, and if said radionuclide or radionuclide complex leaks from said joint it will be excreted from the body, the agent having a particle size such that there is essentially little or no leakage of the radionuclide complex from the joint after administration.

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Venkatesan et al., "Rhenium Heptasulfide: A Potential Carrier System for Radiation Synovectomy", Depts. or Radiology and Orthopedic Surgery, Harvard Medical School, Boston, Mass. 02115.
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