Radionuclide labeling of vitamin B 12 and coenzymes thereof

Details Radionuclide labeling of vitamin B 12 and coenzymes thereof Radionuclide labeling of vitamin B 12 and coenzymes thereof

2006-11-28

2006-11-28

Jones, Dameron L. (Department: 1618)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

C424S001650, C424S001110, C424S001730, C514S052000

Reexamination Certificate

active

07141233

ABSTRACT:
A compound useful for in vivo imaging of organs and tumors is provided of formula:whereinis a cobalamin,is derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is a chelating group, optionally comprising a detectable radionuclide or a paramagnetic metal ion, and n is 1–3.

REFERENCES:
patent: 3936440 (1976-02-01), Nath
patent: 3981863 (1976-09-01), Niswender et al.
patent: 4209614 (1980-06-01), Bernstein et al.
patent: 4279859 (1981-07-01), Gutcho et al.
patent: 4283342 (1981-08-01), Yolles
patent: 4301140 (1981-11-01), Frank et al.
patent: 4465775 (1984-08-01), Houts
patent: 5308606 (1994-05-01), Wilson et al.
patent: 5405839 (1995-04-01), Toraya et al.
patent: 5428023 (1995-06-01), Russell-Jones et al.
patent: 5449720 (1995-09-01), Russell-Jones et al.
patent: 5548064 (1996-08-01), Russell-Jones et al.
patent: 5574018 (1996-11-01), Habberfield et al.
patent: 5589463 (1996-12-01), Russell-Jones et al.
patent: 5608060 (1997-03-01), Axworthy et al.
patent: 5739313 (1998-04-01), Collins et al.
patent: 5807832 (1998-09-01), Russell-Jones et al.
patent: 5840880 (1998-11-01), Morgan et al.
patent: 5869465 (1999-02-01), Morgan et al.
patent: 5869466 (1999-02-01), Russell-Jones et al.
patent: 5877165 (1999-03-01), Miura et al.
patent: 5936082 (1999-08-01), Bauer
patent: 6004533 (1999-12-01), Collins et al.
patent: 6083926 (2000-07-01), Morgan et al.
patent: 6096290 (2000-08-01), Collins et al.
patent: 6150341 (2000-11-01), Russell-Jones et al.
patent: 6183723 (2001-02-01), Seetharam et al.
patent: 6211355 (2001-04-01), Collins et al.
patent: 6262253 (2001-07-01), Russell-Jones et al.
patent: 6315978 (2001-11-01), Grissom et al.
patent: 6613305 (2003-09-01), Collins et al.
patent: 6806363 (2004-10-01), Collins et al.
patent: 2003/0144198 (2003-07-01), Collins et al.
patent: 0005834 (1979-12-01), None
patent: 0069450 (1983-01-01), None
patent: 0165716 (1985-12-01), None
patent: 58-046027 (1981-09-01), None
patent: WO 89/01475 (1989-02-01), None
patent: WO 92/13571 (1992-08-01), None
patent: WO 94/27613 (1994-12-01), None
patent: WO 94/27641 (1994-12-01), None
patent: WO 95/27723 (1995-10-01), None
patent: WO 96/31243 (1996-10-01), None
patent: WO 97/14711 (1997-04-01), None
patent: WO 97/18231 (1997-05-01), None
patent: WO 98/08859 (1998-03-01), None
patent: WO 99/65930 (1999-12-01), None
patent: WO 00/45857 (2000-08-01), None
patent: WO 00/45857 (2000-08-01), None
patent: WO 00/62808 (2000-10-01), None
patent: WO 00/62808 (2000-10-01), None
patent: WO 01/28592 (2001-04-01), None
patent: WO 01/28595 (2001-04-01), None
patent: WO 01/30967 (2001-05-01), None
patent: WO 01/17694 (2001-12-01), None
patent: WO 01/92283 (2001-12-01), None
patent: WO 01/92288 (2001-12-01), None
patent: WO 02/42318 (2002-05-01), None
patent: WO 02/55530 (2002-07-01), None
patent: WO 03/00010 (2003-01-01), None
patent: WO 03/00010 (2003-01-01), None
patent: WO 03/25139 (2003-03-01), None
patent: WO 03/25139 (2003-03-01), None
Alvarez, J., et al., “On a new radiopharmaceutical for kidney imaging”,Int'l J. of Applied Radiation and Isotopes, 25, 283-284 (1974).
Amagasaki, T., et al., “Expression of transcobalamin II receptors by human leukemia K562 and HL-60 cells”,Blood, 76, 1380-1386 (Oct. 1990).
Anderson, C.J., et al., “Preparation, biodistribution and dosimetry of copper-64-labeled anti-colorectal carcinoma monoclonal antibody fragments 1 A3-F(ab')2”,J. Nuc. Med., 36, 850-858 (May 1985).
Anton, D.L., et al., “Carbon-13 nuclear magnetic resonance studies of the monocarboxylic acids of cyanocobalamin, assignments of the b-, d-, and 3-monocarboxylic acids”,J. Am. Chem. Soc., 102, 2215-2219 (Mar. 1980).
Anton, D.L., et al., “The synthesis and properties of four spin-labeled analogs of adenosylcobalamin”,J. Biol. Chem., 255, 4507-4510 (May 1980).
Begley, J.A., et al., “Cobalamin metabolism in cultured human chorionic villus cells”,J. Cell. Physiol., 156, 43-47 (1993).
Blomquist, L., et al., “Uptake of labeled vitamin B21 and 4-iodophenylanine in some tumours of mice”,Experientia, 25, 294, 296 (1969).
Cooper, B.A., et al., “Selective uptake of specifically bound cobalt-58 vitamin B12 by human and mouse tumour cells”,Nature, 191, 393-395 (Jul. 1961).
Cooperman, J.M., “Distribution of radioactive and nonradioactive vitamin B12 in normal and malignant tissues of an infant with neuroblastoma”,Cancer Research, 32, 167-172 (Jan. 1972).
Cooperman, J.M., et al., “Distribution of radioactive and nonradioactive vitamin B12 in the dog”,J. Biol. Chem., 235, 191-194 (Jan. 1960).
Flodh, H., “Accumulation of labeled vitamin B12 in some transplanted tumours”, inDistribution and Kinetics of Labelled Vitamin B12, Acta Radiologica, Supplementum 284, 55-60 (1968).
Flodh, et al., “Accuulation of labeled vitamin B12 in some transplanted tumours”,Int. J. Cancer, 3, 694-499 (1968).
Kaplan, M.A., et al., “Absorptions studies of 59Fe and 58Co vitamin B12 by whole-body radiometry in the radiation therapy of collum carcinoma”,Radiobiol. Radiother., 24, Abstract 745 (1983).
Kikugawa, K., et al., “Direct halogenation of sugar moiety of nucleosides”,Tetrahedron Letters, 2, 87-97 (1971).
Kollmer, W.E., et al., “On a new radiopharmaceutical for kidney imaging”,Int. J. Applied Radiation and Isotopes, 25(6), 283-285 (1974).
Lindemans, J., et al., “Uptake of transcobalamin II-bound cobalamin by HL-60 cells: effect of differentiation induction”,Experimental Cell Research, 184, 449-460 (1989).
Ponto, J.A., “II. Schilling Test”, inPharmaceutical in Medical Imaging, D.P. Swanson, et al., (eds.), MacMillan Publishing Co., Inc., New York, pp. 621-628 (1990).
Smeltzer, et al., Synthesis and characterization of fluorescenct cobalamin (cobalafluor) derivatives for imaging,Organic Letters, 3(6), 799-801 (2001).
Vares, Y.V., et al., “Kinetic of 57 Co-cyanocobalamin distribution in organs and tissues of mice with transplanted tumours”,Eksp. Onkol, 8, Abstract, 33-36 (1986).
Wilbur, et al., “Biotin Reagents for Antibody Pretargeting. 4. Selection of Biotin Conjugates for in Vivo Application Based on Their Dissociation Rate from Avidin and Streptavidin.”Bioconjugate Chem., 11(4), 569-583 (Jun. 29, 2000).
Wilbur, et al., “Evaluation of Biotin-Dye Conjugates for Use in an HPLC Assay to Assess Relative Binding of Biotin Derivatives with Avidin and Streptavidin.”Bioconjugate Chem., 11(4), 584-598 (Jun. 29, 2000).
Woolley, K.E., et al., “Uptake of [Co-57]-vitamin B-12 by murine tumours of many histological types”,Clin. Res., 41, Abstracts of National Meeting, Assoc. Amer. Physicians, p. 73A (Apr. 1993).
Wu, C., et al., Investigation of N-linked macrocycles for 111In and 90Y labeling of proteins,Nucl. Med. Biol., 19, 239-244 (1992).
Allen, R.H, et al., “Isolation of Gastric Vitamin B12-binding Proteins Using Affinity Chromatography,”Journal of Biological Chemistry, 248(10), 3660-3669 (1973).
Allen, R.H., et al., “Isolation of Vitamin B12-binding Proteins Using Affinity Chromatography,”Journal of Biological Chemistry, 247(23), 7695-7701 (1972).
Allen, R.H., “Human Vitamin B12 Transport Proteins,”Progress in Hematology, vol. 9, , pp. 57-84 (1975).
Collins, D., et al., “Tumor Imaging via Indium 111-Labeled DTPA-Adenosylcobalamin”,Mayo Clinic Proc., 74, 687-691 (1999).
Collins, D.A., et al., “Transcobalamin II imaging via radiolabeled diethylene-triaminepentaacetate cobalamin analogs”,J. Nucl. Med., 38(5), 717-723 (1997).
Fedosov, S.N., et al., “Binding of Cobalamin and Cobinamide to Transcobalamin from Bovine Milk,”Biochemistry, 34, 16082-16087 (1995).
Fedosov, S.N., et al., “Transcobalamin from cow milk: isolation and physico-chemical properties,”Biochimica et Biophysica Acta, 1292, 113-119, (1996).
Finkler, A.E., et al., “Nature of the R

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