Radionuclide generator system and method for its preparation and

Details Radionuclide generator system and method for its preparation and Radionuclide generator system and method for its preparation and

1989-09-29

1991-02-05

Anderson, Bruce C.

Radiant energy

Fluent material containment, support or transfer means

With irradiating source or radiating fluent material

C01G 4700

Patent

active

049907875

ABSTRACT:
Improved radionuclide generators include a substantially insoluble salt of a parent radionuclide precursor which may be directly irradiated and then packed in a column for subsequent elution of the daughter radionuclide without the production of counter ion isotopic contaminants. The parent radionuclide precursor is provided in the form of an insoluble salt of the parent element whose counter ion, preferably aluminum, forms a relatively soluble salt with the desired daughter radionuclide. The improved generators may be prepared by reacting a parent radionuclide precursor with aluminum to obtain an aluminum salt of the precursor having low solubility in water, irradiating the aluminum salt to obtain an irradiated aluminum salt of the parent radionuclide, and then disposing the irradiated parent radionuclide in an elutable container. Useful parent radionuclide precursors include molybdenum-98 in the form of molybdate for the production of daughter .sup.99m Tc, as soluble pertechnetate, and tungsten-186 in the form of tungstate for the production of daughter .sup.188 Re as soluble perrhenate. The daughter .sup.99m Tc or .sup.188 Re may be eluting the generator matrix, e.g., with a saline solution.

REFERENCES:
patent: 4123497 (1978-10-01), Ruddock
patent: 4280053 (1981-07-01), Evans et al.
patent: 4859431 (1989-08-01), Ehrhardt

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