Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Coated – impregnated – or colloidal particulate
Patent
1998-04-13
1999-12-07
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Coated, impregnated, or colloidal particulate
424 91, 424 96, 424 111, 604 19, 604 20, A61K 5100, A61M 3614
Patent
active
059978422
ABSTRACT:
Constructs including bars, capsules, beads, and sheets are configured with a radionuclide core that emits energetic particles activating a phosphorescent shell material surrounding the radionuclide core so that it emits light to administer light therapy or PDT. A biocompatible coating that is generally optically transparent encloses the radionuclide core and phosphorescent material to prevent a patient's body in which the constructs are disposed from being affected by any toxicity of the phosphorescent shell material. In a typical application of the constructs, a photoreactive agent is infused into the treatment site and selectively absorbed by abnormal tissue, for example, in a cancerous tumor. Light emitted by the phosphorescent material when activated by the energetic particles emitted from the radionuclide core administers photodynamic therapy, which destroys the abnormal tissue. Particularly, the beads, which are relatively small in size, can be targeted to abnormal tissue by providing a linking mechanism on the biocompatible coating so that the beads are coupled to antibodies found on the abnormal cells, but not on normal tissue. If a glass phosphor material that includes fused quartz or silica glass doped with metal ions is used for the phosphorescent shell material, the beads or other construct must be exposed to IR or other light, causing electrons that have been trapped inside the glass materials to combine with holes, emitting light of a shorter wavelength. The glass phosphor material is preferable, since it is substantially less toxic than other types of scintillators or phosphor materials.
REFERENCES:
patent: 5445608 (1995-08-01), Chen et al.
Deborah Kotz, "Alpha Particle Therapy Poised to Become New Line of Cancer Treatment," The Journal of Nuclear Medicine, Newsline, vol. 39, No. 2, Feb. 1998, pp. 17N-19N and 36N (4pp).
Kate Leggett, "Dosimeter helps monitor prostate cancer treatment," Biophotonics International, Jan.-Feb., 1998, p. 28.
Greg T. Hermanson, "Modification with Synthetic Polymers," Bioconjugate Techniques, Chapter 15, Academic Press, Division of Harcourt Brace & Company, .COPYRGT. 1996 by Academic Press, Inc., pp. 605-629.
Boris M. Krasovitskii, "Organic Scintillators," Organic Luminescent Materials, Chapter 12, .COPYRGT. 1988 by VCH Verlagsgesellschaft mbH, Germany, Library of Congress Card No. 88-20895, pp. 200-210.
Mitsuru Akashi, "Polymers for Pharmaceutical and Biomolecular Engineering," Biomedical Applications of Polymeric Materials, Chapter 6 (Teiji Tsuruta et al., Eds.), .COPYRGT. 1993 by CRC Press, Inc., pp. 371-406.
S.S. Davis and L. Illum, "Particulate Systems for Site Specific Drug Delivery," Targeting of Drugs 4 (G. Gregoriadis et al. Eds.), Plenum Press, New York, 1994, pp. 183-194.
Haruma Kawaguchi, "Polymer Materials for Bioanalysis and Bioseparation," Biomedical Applications of Polymeric Materials, Chapter 5 (Teiji Tsuruta et al., Eds.), .COPYRGT. 1993 CRC Press, Inc., pp. 299-324.
Brenda McCormack and Gregory Gregoriadis, "Polysialic Acids: In Vivo Properties and Possible Uses in Drug Delivery," Targeting of Drugs 4 (G. Gregoriadis et al. Eds.), Plenum Press, New York, 1994, pp. 139-145.
Prof. Dr. G. Blasse and Prof. Dr. B.C. Grabmaier, "X-Ray Phosphors and Scintillators (Counting Techniques)," Luminescent Materials, Chapter 9, .COPYRGT. Springer Verlag Berlin Heidelberg, 1994, pp. 170-194.
Lewis (1993), Hawley's Twelveth Edition Condensed Chemical Dictionary, pp. 142, 907 & 908.
Anderson Ronald M.
Dees Jos,e G.
Jones Dameron
Light Sciences Limited Partnership
LandOfFree
Radionuclide excited phosphorescent material for administering P does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Radionuclide excited phosphorescent material for administering P, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Radionuclide excited phosphorescent material for administering P will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-820437