Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Coated – impregnated – or colloidal particulate
Patent
1997-11-12
2000-09-12
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Coated, impregnated, or colloidal particulate
424 165, 424 111, 424 149, 424 181, 424 169, 534 10, 549347, A61K 5100, A61M 3614
Patent
active
061174130
ABSTRACT:
The invention pertains to compounds which specifically bind radionuclides, and to methods of making radionuclide complexing compounds. In one aspect, the invention includes a radionuclide delivery system comprising: a) a calix[n]arene-crown-[m]-ether compound, wherein n is an integer greater than 3, and wherein m is an integer greater than 3, the calix[n]arene-crown-[m]-ether compound comprising at least two ionizable groups; and b) an antibody attached to the calix[n]arene-crown-[m]-ether compound. In another aspect, the invention includes a method of making a radium complexing compound, comprising: a) providing a calix[n]arene compound, wherein n is an integer greater than 3, the calix[n]arene compound comprising n phenolic hydroxyl groups; b) providing a crown ether precursor, the crown ether precursor comprising a pair of tosylated ends; c) reacting the pair of tosylated ends with a pair of the phenolic hydroxyl groups to convert said pair of phenolic hydroxyl groups to ether linkages, the ether linkages connecting the crown ether precursor to the calix[n]arene to form a calix[n]arene-crown-[m]-ether compound, wherein m is an integer greater than 3; d) converting remaining phenolic hydroxyl groups to esters; e) converting the esters to acids, the acids being proximate a crown-[m]-ether portion of the calix[n]arene-crown-[m]-ether compound; and f) providing a Ra.sup.2+ ion within the crown-[m]-ether portion of the calix[n]arene-crown-[m]-ether compound.
REFERENCES:
patent: 5116614 (1992-05-01), Ehrenfeld
patent: 5246691 (1993-09-01), Geerlings et al.
"Synthesis and Properties of Calixcrown Telomers", by Zhen-Lin Zhong, Chun-Ping Tang, Cai-Ying Wu, and Yuan-Yin Chen. p. 1737. 1995.
"Crown Ether Derivatives of Calix[5]arenes: Synthesis and Complexation Properties", by Francoise Arnaud-Neu, Ralf Arnecke, Volker Bohmer, Stefano Fanni, James L.M. Gordon, Marie-Jose Schwing-Weill and Walter Vogt. p. 1855-1860. 1996.
"Selective Lower Rim Reactions of 5,17-Upper Rim-Disubstituted Calix[4]arenes", by Shiv Kumar Sharma and C. David Gutsche. p. 2654-2568. 1995.
The Feasibility of .sup.255 ac as a source of a-particles in radioimmunotherapy, M.W. Geerlings, et al., Nuclear Medicine Communiations (1993) 14, 121-125.
Potential Use of Alpha Emitting Radionuclides in the Treatment of Cancer, D.S. Wilbur, Antibody, Immunoconjugates and Radiopharmaceuticals, vol. 4, No.1, 1991.
Radionuclides for radioimmunotherapy: criteria for selection, M.W. Geerlings, The International Journal of Biological Markers/ vol. 8 No. 3, pp. 180-186.
Selectivity of Calix[4]arene-crown-6 for Cesium Ion in ISE: Effect of the Conformation, C Bocchi et al., Dipartimento of Chimica, Analytical Chemistry, vol. 87, No. 23, 1995.
Blixt et al J. Am. Chem. Soc., 1995, 117, 8536-8540, "Kinetics and Mechanism of the Sodium Cation complexation by 5,11,17,23-tetra-p-tert-butyl-25,26,27,28-tetramethoxy-calix[4]arene in solution."
Chang, J. Chem. Soc. Perkin Trans. I, 1986, 2, 211-14, "New Metal Cation-Selective Ionophores Derived from Calixarenes: Their Syntheses and Ion-Binding Properties".
Shortreed et al, Anal. Chem, 1996, 68, 2656-2662, "Minature Sodium Selective Ion Exchange Optode with Fluorescent .sup.p H Chromoionophores and Tunable Dynamic Range".
Arduini et al, J. Chem. Soc. Chem. Commun., 1990, 22, 1597-8, Selective-1,2-Functionalization of Calix[4]arenes at the lower rim. Synthesis of a new type of bis-calixcrown ether.
Chen Xiaoyuan
Fisher Darrell R.
Wai Chien M.
Battelle (Memorial Institute)
Dees Jos,e G.
Idaho Research Foundation Inc.
Jones Dameron
LandOfFree
Radionuclide-binding compound, a radionuclide delivery system, a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Radionuclide-binding compound, a radionuclide delivery system, a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Radionuclide-binding compound, a radionuclide delivery system, a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-92992