Radiometal-binding peptide analogues

Details Radiometal-binding peptide analogues Radiometal-binding peptide analogues

1997-07-11

2000-10-03

MacMillan, Keith D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 111, 424 157, 424 165, 424 91, 424 93, 530300, 530317, 530324, 530333, 530334, 530335, 530336, 530337, 530338, 534 10, 534 14, A61K 5100, A61K 4900, A61M 3614, A61B 5055

Patent

active

061269166

ABSTRACT:
Novel metal binding ligands are disclosed that may be coupled to peptides for use in methods of diagnosis and therapy. Peptides containing the ligands are produced using a method wherein ligand introduction or cyclization can be conducted at any point during the synthesis of the peptide. Such peptide derivatives are readily labeled with radiometals, such as isotopes of rhenium or technetium, while retaining their ability to tightly bind specific peptide receptors.

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