Radiometal-binding analogues of luteinizing hormone releasing ho

Details Radiometal-binding analogues of luteinizing hormone releasing ho Radiometal-binding analogues of luteinizing hormone releasing ho

1995-06-07

1998-05-19

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 111, 424 165, 530300, 530328, 534 10, 534 14, A61K 5100, A61M 3614

Patent

active

057532060

ABSTRACT:
Peptide derivatives of leutenizing hormone releasing hormone that are capable of binding radionuclides are provided. The peptide derivatives are readily labeled with isotopes of rhenium or technetium, while retaining their ability to tightly bind LHRH receptors. Methods for preparing the labeled peptides and their use in methods of radiodiagnosis and radiotherapy are described.

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Haberger, T. et al., "Direct Radiolabeling of the Somatostatin Analogs RC-160 and Octreotide with .sup.99m Tc and .sup.133 Re: Initial Results with Strannous Ion Reduction", J. Nucl. Biol. Med. 38:445-446 (1994).
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