Chemistry: analytical and immunological testing – Biospecific ligand binding assay – Utilizing isolate of tissue or organ as binding agent
Reexamination Certificate
2005-01-04
2005-01-04
Ceperley, Mary E. (Department: 1641)
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
Utilizing isolate of tissue or organ as binding agent
C435S007210, C435S040500, C436S166000, C436S172000
Reexamination Certificate
active
06838291
ABSTRACT:
The present invention is directed to the radioligand compound, [35S]-radiolabeled (+)-N-[1′-(6-cyano-1,2,3,4-tetrahydro-2(R)-naphthalenyl)-3,4-dihydro-4(R)-hydoxyspiro[2H-1-benzopyran-2,4′-piperidin]-6-yl]methanesulfonamide. Also within the scope of this invention is a method for identifying compounds that bind to the IKrchannel, and may have antiarrhythmic activity.
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Butcher John W.
Claremon David A.
Connolly Thomas M.
Dean Dennis C.
Karczewski Jerzy
Camara Valerie J.
Ceperley Mary E.
Daniel Mark R.
Merck & Co. , Inc.
Parr Richard S.
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