Radiolabled compounds for thrombus imaging

Details Radiolabled compounds for thrombus imaging Radiolabled compounds for thrombus imaging

1995-05-12

1997-07-08

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 111, 424 165, 530300, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 534 10, 534 14, A61K 5100, A61M 3614

Patent

active

056458150

ABSTRACT:
This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including peptides, that bind to a platelet receptor that is the platelet GPIIb/IIIa receptor, methods and kits for making such compounds, and methods for using such compounds labeled with technetium-99m via a covalently-linked radiolabel-binding moiety to image thrombi in a mammalian body.

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Pearson et al (Apr. 1996). J. Med. Chemistry, vol. 39, No. 7, pp. 1372-1382. Thrombus Imaging Using Technetium-99m Labeled High-Potency GPIIb/IIIa Receptor Antagonists. Chemistry and Initial Biological Studies.
Hartman et al., 1992, "Non-peptide fibrinogen receptor antagonists: 1. Discovery and design of exosite inhibitors", J. Med. Chem. 35: 4640-4642.
Ojima et al., 1992, "Design and Synthesis of New RGD Peptides as Inhibitors of Human Platelet Aggregation", 204th Meeting, Amer. Chem. Soc. Abst. 44.
Knight, 1990, "Radiopharmaceuticals for Thrombus Detection", Sem. Nucl. Med. 20: 52-67.

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