Radiolabelled phenylethyl imidazole carboxylic acid ester...

Details Radiolabelled phenylethyl imidazole carboxylic acid ester... Radiolabelled phenylethyl imidazole carboxylic acid ester...

2008-04-15

2008-04-15

Shameem, Golam M. M. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S300100, C548S333500, C514S396000, C514S399000, C514S400000

Reexamination Certificate

active

11582073

ABSTRACT:
Halogenated carboxylic ester derivatives of phenylethyl imidazole, and their method of preparation are disclosed. Radio-halogenated forms of these compounds are ideally suited for positron-imaging of the adrenal glands, as it is known that these compounds demonstrate a selective and high rate of accumulation in the adrenals. The method of preparing these derivatives proceeds by the conversion of a stable, non-radioactive intermediate having trialkylstannyl leaving groups. These intermediates are efficiently converted to the corresponding halogenated forms by substitution of the trialkylstannyl group with the halogen or radiohalogen.

REFERENCES:
patent: 4770689 (1988-09-01), Van Gestel et al.
patent: 4851424 (1989-07-01), Allgeier
patent: 7189859 (2007-03-01), Zolle et al.

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