Radiolabelled peptide compounds

Details Radiolabelled peptide compounds Radiolabelled peptide compounds

1992-02-05

1995-01-17

Stoll, Robert L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Somatostatin ; related peptides

534 10, 534 14, C07K 726, A61K 4300, A61K 4902

Patent

active

053826540

ABSTRACT:
A diagnostic composition suitable for administration to a warm-blooded animal comprising somatostatin or a molecule capable of interacting with the somatostatin receptor labeled with a radionuclide by means of a chelate ligand capable of administration to an animal to produce reliable visual imaging of tumors or therapeutic effects on tumors.

REFERENCES:
patent: 5225180 (1993-07-01), Dean et al.
J. Nucl. Med., vol. 32, No. 5 (May 1991) Kwekkeboom et al., Abstract No. 305 "[In-111-DTPA-D-Phe]-Octreotide . . . ".
J. Nucl. Med., vol. 31 (1990) Albert et al., Abstract LMIO, "A Somatostatin Analogue to Image-SS-Receptor-Positive-Tumours . . . ".
Paper, 7th Int'l Symposium on Radiopharmacology (1991) Cox et al. "Technetium Labeled Somatostatin . . . ".
J. Nucl. Med., vol. 32, No. 6 (Jun. 1991) Bakker et al., "In Vivo Use of Radioiodinated Somatostatin Analogue", pp. 1184-1188.
J. Nucl. Med., vol. 32, No. 6 (Jun. 1991) Larson, Receptors on Tumors Studied . . . , pp. 1189-1191.
J. Nucl. Med., vol. 31, No. 9 (Sep. 1990) Bakker et al., "Receptor Scintigraphy with a Radioiodinated Somatostatin Analogue", pp. 1501-1509.
J. Nucl. Med., vol. 32, No. 10 (Oct. 1991) Kwekkeboom et al., "Radioiodinated Somatostatin Analogue Scintigraphy . . . ", pp. 1845-1848.

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