Radiolabelled antibody cytotoxic therapy of infectious or autoim

Details Radiolabelled antibody cytotoxic therapy of infectious or autoim Radiolabelled antibody cytotoxic therapy of infectious or autoim

1995-03-27

1997-03-11

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to lymphokine, cytokine, or other secreted growth...

424 149, 424852, A61K 5104, A61K 4505

Patent

active

056098464

ABSTRACT:
Anticancer, antimicrobial and autoimmune disease, and anti-organ rejection therapy using cytotoxic agents is improved using cytokines to prevent, mitigate or reverse adverse radiation-induced or drug-induced toxicity, especially to hematopoietic cells. Cytotoxic agents can include radioisotopes, drugs, toxins and even unconjugated cytotoxic antibodies. A preferred cytokine is IL-1. Higher doses of cytotoxic agents can be administered and tolerated by the patient and dose-limiting marrow toxicity can be prevented, palliated or reversed using adjunct cytokine therapy.

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