Radiolabelled angiotensin converting enzyme inhibitors

Details Radiolabelled angiotensin converting enzyme inhibitors Radiolabelled angiotensin converting enzyme inhibitors

1994-08-02

1997-02-11

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

514300, 514312, 514340, 514252, 514218, 514384, 514383, 544 60, 548537, A61K 5104, A01N 4342, C07D41700, C07D25704

Patent

active

056018010

ABSTRACT:
Angiotensin convening enzyme (ACE) inhibitors can be labelled with Iodine-123, Iodine-125, Iodine-127 or Iodine-131, useful to image the kidneys and lungs for diagnosis and treatment of diseases such as essential hypertension, renal artery stenosis, or diabetes which are associated with a change in the amount of ACE present in the human body.

REFERENCES:
patent: 4374829 (1983-02-01), Harris et al.
patent: 4555502 (1985-11-01), Patchett et al.
patent: 4574079 (1986-03-01), Gavras et al.
patent: 5284849 (1994-02-01), Rosenberg et al.
Gronhagen-Riska et al., "Competitive inhibitor binding assay (CIBA) of captopril and other ACE inhibitors.", Clinica Chimica Acta, 53-60 pp., 162, (1987).
Hwang et al., J. Nucl. Med. 32(9), Sep. 1991, pp. 1730-1737.

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