Radiolabeled tumor imaging agent and method of preparation

Details Radiolabeled tumor imaging agent and method of preparation Radiolabeled tumor imaging agent and method of preparation

1983-04-11

1984-11-27

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

128659, 206569, 424 9, A61K 4300, A61K 4900

Patent

active

044850867

ABSTRACT:
A novel chemical method of labeling porphyrin compounds, specifically hematoporphyrin derivative (HPD), with the radionuclide .sup.111 In or .sup.113m In producing a radioactive tracer material suitable for biomedical applications. HPD labeled with .sup.111 In or .sup.113m In is biologically active in vivo and is preferentially taken up by tumors. This provides a simple and specific means of localizing and detecting neoplasms in man or in animal by scintigraphic imaging techniques.

REFERENCES:
patent: 3961038 (1976-06-01), Benes
patent: 4421735 (1983-12-01), Haber et al.
Cloutour et al., Int. J. Appl. Rad. Isot., 33, (1982), pp. 1311-1318.
Robinson et al., J. Nucl. Med., 23, (1982), p. P38.
Vaum et al., J. Pharmaceutical Sciences, 71, (1982), pp. 1223-1226.

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