Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1989-12-29
1992-05-12
Nucker, Christine
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530317, 530331, 5303911, 530351, 530395, 530408, 530409, 435188, 435217, 424 11, 424 9, 424 8591, 424 851, 424 943, 534 10, 534 14, 514 8, 514 12, 514 21, 549496, 549419, 548548, 548517, 558254, 560110, 560251, C07K 1706, C07K 508, A16K 4902, A16K 3944
Patent
active
051129531
ABSTRACT:
Chelating compounds of specified structure are useful for radiolabeling targeting molecules such as antibodies. Cleavable linkers connect the radionuclide metal chelates to the antibodies. The radiolabeled antibodies have improved biodistribution properties, including reduced localization within the intestines and kidneys.
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Fitzner Jeffrey N.
Gustavson Linda M.
Jones David S.
Kasina Sudhakar
Reno John M.
Kim Kay K.
NeoRx Corporation
Nucker Christine
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