Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1991-01-14
1992-12-29
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530331, 5303913, 530395, 530351, 530408, 530409, 424 11, 534 10, 536 41, 549419, 549496, 548548, 548517, 2609982, 558 17, 558254, 560110, 560251, C07K 1528, C07K 1706, A61K 4902
Patent
active
051752573
ABSTRACT:
Chelating compounds of specified N.sub.2 S.sub.2 N.sub.3 S derived structure are useful for radiolabeling targeting molecules such as antibodies. Cleavable ester orthioester linkers connect the radionuclide metal chelates to the antibodies. The radiolabeled antibodies have improved biodistribution properties, including reduced localization within the intestines and kidneys.
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Fitzner Jeffrey N.
Gustavson Linda M.
Jones David S.
Kasina Sudhakar
Reno John M.
Kim Kay K.
NeoRx Corporation
Nucker Christine M.
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