Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to lymphokine – cytokine – or other secreted growth...
Patent
1994-04-29
1997-02-25
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to lymphokine, cytokine, or other secreted growth...
530402, 530408, 530409, 530351, A61K 4902, A61K 5108, C07K 100
Patent
active
056056710
ABSTRACT:
A method of imaging a target site in an animal's body in which a labelled chemokine is introduced into the animal's body and allowed to accumulate at a target site which includes corresponding receptor molecules. The accumulated, labelled chemokine material then is detected so as to image the target site of the body.
REFERENCES:
patent: 4276280 (1981-06-01), Akerkar et al.
patent: 4520112 (1985-05-01), Snyder et al.
patent: 4656280 (1987-04-01), Garlick
patent: 4659839 (1987-04-01), Nicolotti et al.
patent: 4732974 (1988-03-01), Nicolotti et al.
patent: 4832940 (1989-05-01), Ege
patent: 4837003 (1989-06-01), Nicolotti
patent: 4926869 (1990-05-01), Rubin et al.
patent: 4965392 (1990-10-01), Fritzberg et al.
patent: 4986979 (1991-01-01), Morgan, Jr. et al.
patent: 5037630 (1991-08-01), Fritzberg et al.
patent: 5079228 (1992-01-01), Cohen et al.
patent: 5120525 (1992-06-01), Goldenberg
patent: 5179078 (1993-01-01), Rollins et al.
patent: 5196510 (1993-03-01), Rodwell et al.
patent: 5198424 (1993-03-01), McEver
patent: 5225180 (1993-07-01), Dean et al.
patent: 5241049 (1993-08-01), Goodman et al.
Moser et al., "Neutrophil-activating Peptide 2 . . . or Human Neutrophils*", The Jour. of Biological Chemistry, vol. 266, No. 16, pp. 10666-10671, 1991.
Walz et al., "Generation of the Neutrophil-Activating Peptide NAP-2 From Platlet Basic Protein or Connective Tissue-Activating Peptide III through Monocyte Proteases", J. Exp. Med., vol. 171, pp. 449-454; 1990, Feb.
J. Wang et al., "Human Recombinant Macrophage Inflammatory Protein-1.alpha. and -.beta. and Monocyte . . . ", J. Immunol., vol., 150, No. 7, pp. 3022-3029, (Apr. 1, 1993).
A. K. Samanta et al., "Interleukin 8 (Monocyte-derived Neutrophil Chemotactic Factor) . . . ", J. Biol. & Chem., vol. 285, No. 1, pp. 183-189, (Jan. 6, 1990).
Schnitzel, W., et al., "Neutorphil Activating Peptide-2 Binds with Two Affinities to . . . ", Biochem. & Biophys. Res. Comm., vol. 1, No. 1, pp. 301-307, (Oct. 15, 1991).
Horuk, R., et al., "Purification, Receptor Binding Analysis . . . ", Journ. Biolog. Chem., vol. 268, No. 1, pp. 541-546, (Jan. 5, 1993).
Neote, K., et al., "Identification of a Promiscuous Inflammatory . . . ", Journ. Biolog. Chem., vol. 268, No. 17, pp. 12247-12249, (Jun. 15, 1993).
Besemer, J., et al., "Specific Binding, Internalization, and Degredation of Human . . . ", Journ. Biolog. Chem., vol. 264, No. 29, pp. 17409-17415, (Oct. 15, 1989).
Elner, V. M., et al., "Rapid Communication . . . ", Amer. Journ. Pathol., vol. 136, No. 4, pp. 745-750, (Apr. 1990).
Standiford, T. J., et al., "Disparate Regulation of Interleukin 8 Gene Expression From Blood . . . ", Biochem. & Biophys. Res. Comm., vol. 171, No. 2, pp. 531-536, (Sep. 14, 1990).
Thornton, A. J., et al., "Cytokine-Induced Gene Expression . . . ", J. Immuno., vol. 144, No. 7, pp. 2609-2613, (Apr. 1, 1990).
Samanta, A. K., et al., "Identification and Characterization of Specific Receptors for . . . ", J. Exper. Med., vol. 169, pp. 1185-1189, (Mar. 1989).
Hebert, C. A., et al., "Endothelial and Leukocyte Forms of IL-8 . . . ", J. Immuno., vol. 145, No. 9, pp. 3033-3040, (Nov. 1, 1990).
Darbonne, W. C., et al., "Red Blood Cells Are a Sink for Interleukin 8, a Leukocyte Chemotaxin", J. Clin. Invest., vol. 88, pp. 1362-1369, (Oct. 1991).
Ross, R., "Medical Progress: The Pathogenesis of Atherosclerosis . . . ", New Eng. J. of Med., vol. 314, No. 8, pp. 488-500. (Feb. 20, 1986).
Grob, P. M., et al., "Characterization of a Receptor for Human Monocyte-derived . . . ", J. Biolog. Chem., vol. 265, No. 14, pp. 8311-8316, (May 15, 1990).
Clark-Lewis, I., et al., "Platelet factor 4 binds to interleukin 8 . . . ", Proc. Natl. Acad. Sci., vol. 90, pp. 3574-3577, (Apr. 1993).
Rot, Antal, "Binding of Neutrophil Attractant/Activation Protein-1 . . . ", Chemical Abstracts, vol. 119, No. 21, (Nov. 22, 1993) and Cytokine, vol. 4, No. 5, pp. 347-352, (1992). Abstract.
Vita, N., et al., "Functional Linkage of the Gro.Beta and IL-8 Receptors on the Surface . . . ", Chemical Abstracts, vol. 120, No. 9, and Eur. Cytokine Network, vol. 4, No. 3, pp. 197-204, (1993). Abstract.
Kunkel Steven L.
Lyle Leon R.
Strieter Robert M.
Hartley Michael G.
Hollinden Gary E.
Mallinckrodt Medical Inc.
The Regents of the University of Michigan
LandOfFree
Radiolabeled neutrophil activating peptides for imaging does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Radiolabeled neutrophil activating peptides for imaging, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Radiolabeled neutrophil activating peptides for imaging will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1972563