Radiolabeled neoglycopeptides

Details Radiolabeled neoglycopeptides Radiolabeled neoglycopeptides

1980-03-03

1983-08-30

Gron, Teddy S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

424 9, 128659, A61K 4300, A61K 3702, A61K 4902

Patent

active

044016476

ABSTRACT:
Radiopharmaceuticals and method are provided for scintigraphic evaluation of the liver. The radiopharmaceuticals comprise a radionuclide (technetium) labeled neoglycoprotein which provides for specific binding of the radiopharmaceutical to hepatocytes and allows for accurate determination of rates of binding and release of Tc-99m to and from the liver. The observed rates may then be used to determine diseased states, conveniently using an appropriate algorithm for the calculation.

REFERENCES:
patent: 4010251 (1977-03-01), Green
Radiopharmaceuticals 2: Proceedings, 2nd International Symposium, (Mar. 19-22, 1979,) pp. 565-576, Sorenson, J. A. Ed.
David R. Vera et al., "Radioligands That Bind to Cell-Specific Receptors: Hepatic Binding Protein Fugands for Hepatic Scintigraphy".
American Journal of Roentgenology, vol. 132, No. 3, p. 492, Abstract 36 (1979) Vera, D. R. et al. "Radioligand . . . ".
J. Biol. Chem. 253(17), pp. 6107-6110 (1978) Stowell, C. P. & Lee, Y. C.
"Am. J. Roentgenol, 132(3) p. 492(1979) Vera, D. R. et al.

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