Radiolabeled farnesyl-protein transferase inhibitors

Details Radiolabeled farnesyl-protein transferase inhibitors Radiolabeled farnesyl-protein transferase inhibitors

1998-05-07

2000-05-09

Dees, Jose' G.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 185, 424 189, 544336, 544386, 544392, 544406, A61K 5104, C07D24100

Patent

active

060600381

ABSTRACT:
The present invention is directed toward radiolabeled farnesyl-protein transferase inhibitor compounds which are useful to label FPTase in assays, whether cell-based, tissue-based or in whole animal. The tracers can also be used in competitive binding assays to obtain information on the interaction of unlabeled FTIs with FPTase.

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