Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1986-05-30
1988-08-16
Terapane, John F.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
260408, A61K 4902, A61K 4300, C11C 300
Patent
active
047643587
ABSTRACT:
A radiolabeled long chain fatty acid for heart imaging that has dimethyl branching at one of the carbons of the chain which inhibits the extent to which oxidation can occur. The closer to the carboxyl the branching is positioned, the more limited the oxidation, thereby resulting in prolonged retention of the radiolabeled compound in the heart.
REFERENCES:
patent: 4290965 (1981-09-01), Stocklin et al.
patent: 4323547 (1982-04-01), Knust et al.
patent: 4450149 (1984-05-01), Kabalka
patent: 4473544 (1984-09-01), Machulla et al.
patent: 4476106 (1984-10-01), Bardy et al.
patent: 4523033 (1985-06-01), Knapp, Jr. et al.
patent: 4524059 (1985-06-01), Elmaleh et al.
Otto et al, J. Labelled Compounds & Radiopharmaceuticals, XIX, Nos. 11-12, 1312-1313, 1982.
Knapp et al, Presented at the Proceedings of the International Symposium of the Developing Role of Short-Lived Radionuclides in Nuclear Medical Practice, Wash. D.C., May 1982.
Goodman et al, Presented at the 5th International Symposium on Radio Pharmaceutical Chemistry, Japan, Jun. 1984.
"Synthesis and Evaluation of Radioiodinated Terminal p-Iodophenyl-Substituted Alpha and Beta Methyl Branched Fatty Acids"; M. M. Goodman et al, J. Med. Chem. 1984, 27, 390-397.
"Regional Myocardial Substrate Uptake in Hypertensive Rats: A Quantitative Autoradiographic Measurement"; Yoshiharu Yonekura et al; Science; Mar. 22, 1985, pp. 1494-1496.
"Synthesis of 15-(p-Iodophenyl)-6telluapentadecanoic Acid: A New Myocardial Imaging Agent"; M. M. Goodman et al; J. Org. Chem., 1982, 47, pp. 3004-3006.
"New Myocardial Imaging Agents: Synthesis of 15(p-Iodophenyl)-3(R,S)-methylpentadecanoic Acid by Decompoition of a 3,3-(1,5-Pentanediyl)-triazene Precursor"; M. M. Goodman et al, J. Org. Chem., 1984, 49, pp. 2322-2325.
"The Design and Biologicak Properties of Iodine-123 Labeled beta-Methyl Branched Fatty Acids"; Furn F. Knapp et al; European Heart Journal, vol. 14 (1985)6(Supplement B), pp. 71-83.
"Radioiodinated 15(p-Iodophenyl)-3,3-Dimethylpentadecanoic Acid: A Useful New Agent to Evaluate Myocardial Fatty Acid Uptake" Furn F. Knapp et al; J. Nucl. Med. 27, No. 4, pp. 521-531, Apr. 1986.
Goodman Mark M.
Kirsch Gilbert
Knapp, Jr. Furn F.
Hamel Stephen D.
Hightower Judson R.
Lovingood Katherine P.
Terapane John F.
The United States of America as represented by the United States
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