Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-06-03
1998-11-03
Davenport, Avis M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
A61K 3800, A61K 3802, C07K 500, C07K 700
Patent
active
058308563
ABSTRACT:
This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including peptides, that bind to a platelet receptor that is the platelet GPIIb/IIIa receptor, methods and kits for making such compounds, and methods for using such compounds labeled with technetium-99m via a covalently-linked radiolabel-binding moiety to image thrombi in a mammalian body.
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Parise & Phillips, 1985, "Reconstitution of the Purified Platelet fibrinogen Receptor: Fibrinogen Binding Properties of the Glycoprotein IIb-IIIa Complex", J. Biol. Chem. 260: 10698-10707.
Knight, 1990, "Radiopharmceuticals for Thrombus Detection", Sem. Nucl. Med. 20:52-67.
Ojima et al., 1992, "Design and Synthesis of New RGD Peptides as Inhibitors of Human Platelet Aggregation", 204th Meeting, Amer. Chem. Soc. Abst. 44.
Hartman et al., 1992, "Non-peptide Fibrinogen Receptor Antagonists. 1. Discovery and Design of Exosite Inhibitors", J. Med. Chem. 35: 4640-4642.
Civitello Edgar R.
Dean Richard T.
Lister-James John
McBride William
Davenport Avis M.
Diatide, Inc.
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