Radiolabeled antiplatelet monoclonal antibody for imaging in-viv

Details Radiolabeled antiplatelet monoclonal antibody for imaging in-viv Radiolabeled antiplatelet monoclonal antibody for imaging in-viv

1992-01-21

1993-07-06

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

5303913, 43524027, 935107, A61K 4902, A61K 39395

Patent

active

052251810

ABSTRACT:
There is provided a radiolabeled monoclonal antibody of the class IgG.sub.1 which reacts readily with both normal human and dog blood platelets while failing to react with thrombasthenic human platelets. This antibody has the property of completely blocking interaction of fibrinogen with platelets induced by ADP, and the ability to detect fresh thrombi in vivo.

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