Radiolabeled antibody to anti-tumor associated antigen and proce

Details Radiolabeled antibody to anti-tumor associated antigen and proce Radiolabeled antibody to anti-tumor associated antigen and proce

1986-02-03

1987-05-12

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

206569, 422 61, 424 9, A61K 4300, A61K 4902

Patent

active

RE0324175

ABSTRACT:
Antibodies to human carcinoembryonic antigen (CEA), human alphafetoprotein (AFP) and/or to other anti-human tumor associated antigens (TAA) labeled with technetium-99m (Tc-99m) are administered to a human after the human has been administered anti-CEA, anti-AFP and/or other anti-TAAs, such as human melanoma-associated antigen, human neuroblastoma-associated antigen, human breast cancer-associated antigen, human ovary-associated antigen, human sarcoma-associated antigen, etc. The biodistribution of the labeled product composition accumulates at cancer sites, e.g., tumors that produce or express TAA, due to the affinity that the antibody has for the given tumor antigen. The accumulation at the tumor site(s) of a suitable amount of Tc-99m associated with the antibody allows detection via external scintigraphy and other means. Detection of the Tc-99m antibody composition by external scintigraphy permits localization and detection of tumors in vivo via a semi-noninvasive technique.

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patent: 4311688 (1982-01-01), Burchiel et al.
patent: 4323546 (1982-04-01), Crockford
patent: 4361544 (1982-11-01), Goldenberg

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