Radiolabeled antibody fragments

Details Radiolabeled antibody fragments Radiolabeled antibody fragments

1984-09-13

1989-06-06

Warden, Robert J.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424 8591, 436512, 436547, 436548, 436804, 436813, 935107, 530388, 530391, G01N 33534, G01N 33563

Patent

active

048370037

ABSTRACT:
Methods and reagents for attaching radionuclide metal ions to antibody fragments are disclosed. A coupling agent is employed which contains a maleimidyl group linked, through a divalent organic moiety, to a group capable of forming a chelate complex with the radionuclide metal ion. Antibody fragments labeled with radionuclide metal ions by the disclosed procedure are useful for in vivo diagnostic or therapeutic applications.

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