Radioisotopicassay using isotope transfer to chelator-target rec

Details Radioisotopicassay using isotope transfer to chelator-target rec Radioisotopicassay using isotope transfer to chelator-target rec

1987-01-23

1988-09-20

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

436518, 436531, 436542, 436545, 436804, 436808, 435 7, 435810, 530402, 530403, 530405, 530406, 536 11, 536 26, 536 27, 536 28, G01N 33543, G01N 33536, C12Q 170

Patent

active

047725486

ABSTRACT:
A method of forming a therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises: contacting an unlabeled therapeutic or diagnostic agent, consisting of a substantially non-metal chelating portion and a chelating portion capable of chelating with the radioactive metal ion, with an ion transfer material having the radioactive metal ion bound thereto and having a binding affinity for the radioactive metal less than the binding affinity of the chelating portion for the radioactive metal ion, wherein prior to contacting the chelating portion is unchelated or is chelated with a second metal having a binding affinity with the chelating portion less than the binding affinity of the radioactive metal ion, whereby a radiolabeled therapeutic or diagnostic agent is formed by the contacting, and separating the radiolabeled therapeutic or diagnostic agent from the ion transfer material, is disclosed along with various components and kits useful in practicing this method and several variations thereof.

REFERENCES:
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patent: 4272503 (1981-06-01), Camin et al.
patent: 4305922 (1981-12-01), Rhodes
patent: 4652519 (1987-03-01), Warshawsky et al.
patent: 4672028 (1987-06-01), Olson
Meares et al., Proc. Nat. Acad. Sci. USA, 69, 3718-3722 (1972).
DeRiemer et al., J. Med. Chem., 22, 1019-1023 (1979).

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