Radioiodinated sulfonated phenols and process therefore

Details Radioiodinated sulfonated phenols and process therefore Radioiodinated sulfonated phenols and process therefore

2005-03-01

2005-03-01

Hartley, Michael G. (Department: 1616)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

Reexamination Certificate

active

06861044

ABSTRACT:
The present invention concerns the use of a radioiodinated phenolic compound of the formulawherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged at physiological pH, R, R1, R2and R3are independently hydrogen, C1-C4alkyl, or a carboxyl group, and I* is123I,131I or125I, and its pharmaceutically-acceptable salts. The compound is formulated and used in vivo in an animal in brachytherapy in an implantable catheter. In addition, due to the rapid renal clearance of these compounds, they may be used to study renal function. A process to prepare these compounds is also disclosed.

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