Radioiodinated phospholipid ether analogues and methods of using

Details Radioiodinated phospholipid ether analogues and methods of using Radioiodinated phospholipid ether analogues and methods of using

1992-02-10

1994-09-13

Stoll, Robert L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

C07F 909

Patent

active

053470303

ABSTRACT:
Novel radioiodinated analogues of naturally-occurring phospholipid ethers are tumor-specific and have a triglycerol backbone structure which, in certain embodiments, is substituted at the 3-position with an alkyl phosphocholine and include a monoiodinated benzoyl side chain substituted at the 2-position in accordance with the general formula: ##STR1## where n= 1-15 ##STR2## m= 0-15; Z=.sup.123 I, .sup.125 I, and .sup.131 I; Y=NH.sub.2, NR.sub.2, and NR.sub.3, and R=alkyl, aralkyl.

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patent: 5087721 (1992-02-01), Counsell et al.

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