Radioiodinated maleimides and use as agents for radiolabeling an

Details Radioiodinated maleimides and use as agents for radiolabeling an Radioiodinated maleimides and use as agents for radiolabeling an

1987-04-28

1988-04-05

Terapane, John F.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

548549, 424 9, A61K 4902, C07D207244

Patent

active

047357924

ABSTRACT:
A radiopharmaceutical for antibody labeling comprising an iodophenyl maleimide that attaches thiol sites of proteins thereby maintaining bioreactivity largely located at the nitrogen sites.

REFERENCES:
patent: 4659839 (1987-04-01), Nicolotti et al.
Ogawa et al, "Fate of Fluoroimide", Nippon Noyaku Gakkaishi, 1980, 5(1), 29-36.
Ohori et al., "In Vitro Metabolism of Fluoroimide", Nippon Noyaku Gakkaishi, 1983, 8(2), 223-227.
Bolton et al, "The Labelling of Proteins . . . ", Biochem. J. (1973), 133, 529-539.
Yano et al, "Gallium-68 Lipophilic Complexes for Labeling Platelets", J. Nucl. Med. 26:1429-1437, 1985.
Duncan et al, "A New Reagent Which May Be Used . . . ", Anal. Biochemistry 132, 68-73 (1983).
Fritzberg, Ed., "Radiopharmaceuticals: Progress and Clinical Perspectives, vol. II", pp. 2-60.
Mills et al, "Platelets and Thrombosis", Proceedings of the Serono Symposia, vol. 10.
Immunoassay, Suppl. 1, Sep. 1980, pp. 6-8.

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