Radioiodinated benzamines method of their use as radioimaging ag

Details Radioiodinated benzamines method of their use as radioimaging ag Radioiodinated benzamines method of their use as radioimaging ag

1991-05-28

1992-10-13

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

514359, 514428, 548567, A61K 4902, A61K 3141

Patent

active

051549131

ABSTRACT:
Novel, substituted benzamides in radioiodinated form are useful in radiopharmaceutical compositions in nuclear medicine as imaging agents to detect, visualize, and analyze the distribution and function of the dopamine D-2 receptor in the mammalian brain. The substituted benzamides and their racemic mixtures or their optically resolved enantiomers can be made by reacting a trialyltin substituted benzamide with an acid in the presence of radioactive iodine, generated by in situ oxidation of an appropriate iodide nuclide salt.

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Hall, et al, "Catechol Derivatives," E.P. 207,913, Jan. 1987, C.A. 106: 113551, vol. 106, 1987, p. 58.

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